Blowing off acid: a new tool to study Na+/HCO3- co-transport

TY - JOUR

T1 - Blowing off acid: a new tool to study Na+/HCO3- co-transport

AU - Avkiran, M

PY - 2008/3

Y1 - 2008/3

N2 - Investigation of the physiological functions and possible pathological roles of Na+/HCO3- co-transport in the heart has been hampered by uncertainty over the molecular identity of cardiac Na+/HCO3- co-transporter(s) and the absence of selective pharmacological inhibitors. In their paper published in this issue, Ch'en and colleagues describe the extensive characterization of S0859 as a high-affinity inhibitor of Na+/HCO3- co-transport in cardiac myocytes (Ch'en et al., 2008). The availability of S0859 provides a powerful new tool to investigate the (patho) physiological significance of Na+/HCO3- co-transport in the heart and other tissues

AB - Investigation of the physiological functions and possible pathological roles of Na+/HCO3- co-transport in the heart has been hampered by uncertainty over the molecular identity of cardiac Na+/HCO3- co-transporter(s) and the absence of selective pharmacological inhibitors. In their paper published in this issue, Ch'en and colleagues describe the extensive characterization of S0859 as a high-affinity inhibitor of Na+/HCO3- co-transport in cardiac myocytes (Ch'en et al., 2008). The availability of S0859 provides a powerful new tool to investigate the (patho) physiological significance of Na+/HCO3- co-transport in the heart and other tissues

U2 - 10.1038/sj.bjp.0707670

DO - 10.1038/sj.bjp.0707670

M3 - Editorial

SN - 1476-5381

VL - 153

SP - 844

EP - 845

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 5

ER -