Blowing off acid: a new tool to study Na+/HCO3- co-transport

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1 Citation (Scopus)


Investigation of the physiological functions and possible pathological roles of Na+/HCO3- co-transport in the heart has been hampered by uncertainty over the molecular identity of cardiac Na+/HCO3- co-transporter(s) and the absence of selective pharmacological inhibitors. In their paper published in this issue, Ch'en and colleagues describe the extensive characterization of S0859 as a high-affinity inhibitor of Na+/HCO3- co-transport in cardiac myocytes (Ch'en et al., 2008). The availability of S0859 provides a powerful new tool to investigate the (patho) physiological significance of Na+/HCO3- co-transport in the heart and other tissues
Original languageEnglish
Pages (from-to)844 - 845
Number of pages2
JournalBritish Journal of Pharmacology
Issue number5
Publication statusPublished - Mar 2008


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