BMP1-related metallproteinases promote the development of ventral mesoderm in early Xenopus embryos

Shelley A Goodman, Roldolpho Albano, Fiona C Wardle, Glenn Matthews, David Tannahill, Leslie Dale

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)


Bone morphogenetic protein 1 (BMP1) is a metalloproteinase closely related to Drosophila Tolloid (Tld). Tld regulates dorsoventral patterning in early Drosophila embryos by enhancing the activity of Dpp, a member of the TGF-beta family most closely related to BMP2 and BMP4. In Xenopus BMP4 appears to play an essential role in dorsoventral patterning, promoting the development of ventral fates during gastrula stages. To determine if BMP1 has a role in regulating the activity of BMP4, we have isolated cDNAs for Xenopus BMP1 and a novel closely related gene that we have called xolloid (xld). Whereas xbmp1 is uniformly expressed at all stages tested, the initial uniform expression of xld becomes localized to two posterior ectodermal patches flanking the neural plate and later to the inner ectoderm of the developing tailbud. xld is also expressed in dorsal regions of the brain during tailbud stages and is especially abundant in the ventricular layer of the dorsal hindbrain caudal to the otic vesicle. Overexpression of either gene inhibits the development of dorsoanterior structures in whole embryos and ventralizes activin-induced dorsal mesoderm in animal caps. Since ventralization of activin-induced animal caps can be blocked by coinjecting a dominant-inhibitory receptor for BMP2 and BMP4, we suggest a role for BMP1 and Xld in regulating the ventralizing activity of these molecules. (C) 1998 Academic Press.
Original languageEnglish
Pages (from-to)144 - 157
Number of pages14
JournalDevelopmental Biology
Issue number2
Publication statusPublished - 15 Mar 1998


Dive into the research topics of 'BMP1-related metallproteinases promote the development of ventral mesoderm in early Xenopus embryos'. Together they form a unique fingerprint.

Cite this