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Body site-specific genetic effects influence naevus count distribution in women

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Body site-specific genetic effects influence naevus count distribution in women. / Visconti, Alessia; Ribero, Simone; Sanna, Marianna; Spector, Timothy D; Bataille, Veronique; Falchi, Mario.

In: Pigment cell & melanoma research, 12.08.2019.

Research output: Contribution to journalArticle

Harvard

Visconti, A, Ribero, S, Sanna, M, Spector, TD, Bataille, V & Falchi, M 2019, 'Body site-specific genetic effects influence naevus count distribution in women', Pigment cell & melanoma research. https://doi.org/10.1111/pcmr.12820

APA

Visconti, A., Ribero, S., Sanna, M., Spector, T. D., Bataille, V., & Falchi, M. (2019). Body site-specific genetic effects influence naevus count distribution in women. Pigment cell & melanoma research. https://doi.org/10.1111/pcmr.12820

Vancouver

Visconti A, Ribero S, Sanna M, Spector TD, Bataille V, Falchi M. Body site-specific genetic effects influence naevus count distribution in women. Pigment cell & melanoma research. 2019 Aug 12. https://doi.org/10.1111/pcmr.12820

Author

Visconti, Alessia ; Ribero, Simone ; Sanna, Marianna ; Spector, Timothy D ; Bataille, Veronique ; Falchi, Mario. / Body site-specific genetic effects influence naevus count distribution in women. In: Pigment cell & melanoma research. 2019.

Bibtex Download

@article{4db48e55646047fb90df9333442557a3,
title = "Body site-specific genetic effects influence naevus count distribution in women",
abstract = "Body site is highly relevant for melanoma: it affects prognosis and varies according to the patient's sex. The distribution of naevi, a major risk factor for melanoma, at different body sites also varies according to sex in childhood. Using naevus counts at different body sites in 492 unrelated adults from both sexes, we observed that women have an increased number of naevi on the lower limbs compared to men (P=8.5x10-5 ), showing that a high naevus count on this site persists from childhood throughout life. Then, using data from 3,232 twins, we observed, in women, the lowest naevus count heritability on the trunk (26%), and the highest on the lower limbs (69%). Finally, we showed that, in 2,864 women, six genomic loci previously associated with both naevus count and melanoma risk (IRF4, DOCK8, MTAP, 9q31.2, KITLG, and PLA2G6) have an effect on naevus count that is body site-specific, but whose effect sizes are predominantly stronger on the lower limbs. Sex-specific genetic influence on naevus count at different sites may explain differences in site-specific melanoma incidence as well as prognosis between sexes. This article is protected by copyright. All rights reserved.",
keywords = "Candidate Gene Association Study, heredity, lower extremity, melanoma, naevus",
author = "Alessia Visconti and Simone Ribero and Marianna Sanna and Spector, {Timothy D} and Veronique Bataille and Mario Falchi",
note = "This article is protected by copyright. All rights reserved.",
year = "2019",
month = aug,
day = "12",
doi = "10.1111/pcmr.12820",
language = "English",
journal = "Pigment cell & melanoma research",
issn = "1755-1471",
publisher = "Wiley-Blackwell",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Body site-specific genetic effects influence naevus count distribution in women

AU - Visconti, Alessia

AU - Ribero, Simone

AU - Sanna, Marianna

AU - Spector, Timothy D

AU - Bataille, Veronique

AU - Falchi, Mario

N1 - This article is protected by copyright. All rights reserved.

PY - 2019/8/12

Y1 - 2019/8/12

N2 - Body site is highly relevant for melanoma: it affects prognosis and varies according to the patient's sex. The distribution of naevi, a major risk factor for melanoma, at different body sites also varies according to sex in childhood. Using naevus counts at different body sites in 492 unrelated adults from both sexes, we observed that women have an increased number of naevi on the lower limbs compared to men (P=8.5x10-5 ), showing that a high naevus count on this site persists from childhood throughout life. Then, using data from 3,232 twins, we observed, in women, the lowest naevus count heritability on the trunk (26%), and the highest on the lower limbs (69%). Finally, we showed that, in 2,864 women, six genomic loci previously associated with both naevus count and melanoma risk (IRF4, DOCK8, MTAP, 9q31.2, KITLG, and PLA2G6) have an effect on naevus count that is body site-specific, but whose effect sizes are predominantly stronger on the lower limbs. Sex-specific genetic influence on naevus count at different sites may explain differences in site-specific melanoma incidence as well as prognosis between sexes. This article is protected by copyright. All rights reserved.

AB - Body site is highly relevant for melanoma: it affects prognosis and varies according to the patient's sex. The distribution of naevi, a major risk factor for melanoma, at different body sites also varies according to sex in childhood. Using naevus counts at different body sites in 492 unrelated adults from both sexes, we observed that women have an increased number of naevi on the lower limbs compared to men (P=8.5x10-5 ), showing that a high naevus count on this site persists from childhood throughout life. Then, using data from 3,232 twins, we observed, in women, the lowest naevus count heritability on the trunk (26%), and the highest on the lower limbs (69%). Finally, we showed that, in 2,864 women, six genomic loci previously associated with both naevus count and melanoma risk (IRF4, DOCK8, MTAP, 9q31.2, KITLG, and PLA2G6) have an effect on naevus count that is body site-specific, but whose effect sizes are predominantly stronger on the lower limbs. Sex-specific genetic influence on naevus count at different sites may explain differences in site-specific melanoma incidence as well as prognosis between sexes. This article is protected by copyright. All rights reserved.

KW - Candidate Gene Association Study

KW - heredity

KW - lower extremity

KW - melanoma

KW - naevus

UR - http://www.scopus.com/inward/record.url?scp=85071045125&partnerID=8YFLogxK

U2 - 10.1111/pcmr.12820

DO - 10.1111/pcmr.12820

M3 - Article

C2 - 31403758

JO - Pigment cell & melanoma research

JF - Pigment cell & melanoma research

SN - 1755-1471

ER -

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