King's College London

Research portal

Bone, Stem Cells and Regeneration: Tissue Engineering Approaches

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish
JournalThe Encyclopedia of Life Sciences
Published27 May 2020

Documents

King's Authors

Abstract

The potential for regenerating bone and cartilage for cell-based therapies has increased markedly in the past decades primarily due to advances in the understanding of molecular controls of embryonic skeletal development, in identification of refined stem cell/progenitor populations that are suitable for tissue regeneration, and in the discoveries of novel biomaterials that can mimic tissue architecture. In particular, modelling how the embryo makes the appropriate molecular decisions to fine tune the development of specific bone and cartilage subpopulations that form the complex skeleton has provided a platform upon which regenerative strategies can be translated to the clinic. It is therefore imperative to understand the basic biology of bone and skeletal tissues and apply lessons from developmental biology to identify the unique and appropriate cell populations that have potent regenerative potential when combined with optimal biomaterials.

Download statistics

No data available

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454