Botulinum Toxin-A Treatment Reduces Human Mechanical Pain Sensitivity and Mechanotransduction

Kathryn Paterson; Stephane Lolignier; John N. Wood; Stephen B. McMahon; David L. H. Bennett

doi:10.1002/ana.24122

Botulinum Toxin-A Treatment Reduces Human Mechanical Pain Sensitivity and Mechanotransduction

Kathryn Paterson, Stephane Lolignier, John N. Wood, Stephen B. McMahon, David L. H. Bennett^*

^*Corresponding author for this work

Wolfson SPaRC

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

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Abstract

The mechanisms underlying the analgesic effects of botulinum toxin serotype A (BoNT-A) are not well understood. We have tested the hypothesis that BoNT-A can block nociceptor transduction. Intradermal administration of BoNT-A to healthy volunteers produced a marked and specific decrease in noxious mechanical pain sensitivity, whereas sensitivity to low-threshold mechanical and thermal stimuli was unchanged. BoNT-A did not affect cutaneous innervation. In cultured rodent primary sensory neurons, BoNT-A decreased the proportion of neurons expressing slowly adapting mechanically gated currents linked to mechanical pain transduction. Inhibition of mechanotransduction provides a novel locus of action of BoNT-A, further understanding of which may extend its use as an analgesic agent.

Original language	English
Pages (from-to)	591-596
Number of pages	6
Journal	Annals of Neurology
Volume	75
Issue number	4
Early online date	18 Feb 2014
DOIs	https://doi.org/10.1002/ana.24122
Publication status	Published - Apr 2014

Keywords

NEUROPATHIC PAIN
SENSORY NEURONS
SECONDARY HYPERALGESIA
EVOKED PAIN
MODEL
SENSITIZATION
NOCICEPTORS
EXOCYTOSIS
NEUROTOXIN
CAPSAICIN

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Botulinum Toxin-A Treatment_PATTERSON_Acc11Feb2014Epub18Feb2014_GOLD VoR(CC BY)Final published version, 360 KBLicence: CC BY

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title = "Botulinum Toxin-A Treatment Reduces Human Mechanical Pain Sensitivity and Mechanotransduction",

abstract = "The mechanisms underlying the analgesic effects of botulinum toxin serotype A (BoNT-A) are not well understood. We have tested the hypothesis that BoNT-A can block nociceptor transduction. Intradermal administration of BoNT-A to healthy volunteers produced a marked and specific decrease in noxious mechanical pain sensitivity, whereas sensitivity to low-threshold mechanical and thermal stimuli was unchanged. BoNT-A did not affect cutaneous innervation. In cultured rodent primary sensory neurons, BoNT-A decreased the proportion of neurons expressing slowly adapting mechanically gated currents linked to mechanical pain transduction. Inhibition of mechanotransduction provides a novel locus of action of BoNT-A, further understanding of which may extend its use as an analgesic agent.",

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author = "Kathryn Paterson and Stephane Lolignier and Wood, {John N.} and McMahon, {Stephen B.} and Bennett, {David L. H.}",

year = "2014",

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doi = "10.1002/ana.24122",

language = "English",

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T1 - Botulinum Toxin-A Treatment Reduces Human Mechanical Pain Sensitivity and Mechanotransduction

AU - Paterson, Kathryn

AU - Lolignier, Stephane

AU - Wood, John N.

AU - McMahon, Stephen B.

AU - Bennett, David L. H.

PY - 2014/4

Y1 - 2014/4

N2 - The mechanisms underlying the analgesic effects of botulinum toxin serotype A (BoNT-A) are not well understood. We have tested the hypothesis that BoNT-A can block nociceptor transduction. Intradermal administration of BoNT-A to healthy volunteers produced a marked and specific decrease in noxious mechanical pain sensitivity, whereas sensitivity to low-threshold mechanical and thermal stimuli was unchanged. BoNT-A did not affect cutaneous innervation. In cultured rodent primary sensory neurons, BoNT-A decreased the proportion of neurons expressing slowly adapting mechanically gated currents linked to mechanical pain transduction. Inhibition of mechanotransduction provides a novel locus of action of BoNT-A, further understanding of which may extend its use as an analgesic agent.

AB - The mechanisms underlying the analgesic effects of botulinum toxin serotype A (BoNT-A) are not well understood. We have tested the hypothesis that BoNT-A can block nociceptor transduction. Intradermal administration of BoNT-A to healthy volunteers produced a marked and specific decrease in noxious mechanical pain sensitivity, whereas sensitivity to low-threshold mechanical and thermal stimuli was unchanged. BoNT-A did not affect cutaneous innervation. In cultured rodent primary sensory neurons, BoNT-A decreased the proportion of neurons expressing slowly adapting mechanically gated currents linked to mechanical pain transduction. Inhibition of mechanotransduction provides a novel locus of action of BoNT-A, further understanding of which may extend its use as an analgesic agent.

KW - NEUROPATHIC PAIN

KW - SENSORY NEURONS

KW - SECONDARY HYPERALGESIA

KW - EVOKED PAIN

KW - MODEL

KW - SENSITIZATION

KW - NOCICEPTORS

KW - EXOCYTOSIS

KW - NEUROTOXIN

KW - CAPSAICIN

U2 - 10.1002/ana.24122

DO - 10.1002/ana.24122

M3 - Article

SN - 0364-5134

VL - 75

SP - 591

EP - 596

JO - Annals of Neurology

JF - Annals of Neurology

IS - 4

ER -

Botulinum Toxin-A Treatment Reduces Human Mechanical Pain Sensitivity and Mechanotransduction

Abstract

Keywords

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