Brain activation during human defensive behaviour: a systematic review and preliminary meta-analysis

Fiona Patrick; Matthew J. Kempton; Lindsey Marwood; Steven C. R. Williams; Allan H. Young; Adam M. Perkins

doi:10.1016/j.neubiorev.2018.12.028

Brain activation during human defensive behaviour: a systematic review and preliminary meta-analysis

Fiona Patrick, Matthew J. Kempton, Lindsey Marwood, Steven C. R. Williams, Allan H. Young, Adam M. Perkins

Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. Electronic address: [email protected].
SLaM South London and Maudsley NHS Foundation Trust
Diabetes Psychiatry & Psychology, Department of Psychological Medicine and Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
King's College London
Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; National Institute for Health Research, Biomedical Research Centre, South London & Maudsley NHS Foundation Trust, London, UK.

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

352 Downloads (Pure)

Abstract

The neural underpinnings of defensive behaviour have implications for both basic research and clinical translation. This review systematically collates published research on neural response during simple avoidance of threat and approach-avoidance behaviour during goal-conflicting situations and presents an exploratory meta-analysis of available whole-brain data. Scopus, PsychInfo and Web of Science databases were searched for the period up to March 2018. 1,348 simple avoidance and 1,910 goal-conflict publications were initially identified; following review, 8 simple avoidance and 11 goal-conflict studies were included, with 5 datasets used in a preliminary meta-analysis. A move from forebrain-to-midbrain activation as threat becomes more pertinent was noted, indicating support for the Reinforcement Sensitivity Theory of behaviour and general compatibility with animal work. However, these findings were not reflected in the subsequent preliminary meta-analysis. This review highlights the considerable heterogeneity in currently available defensive behaviour paradigms and the lack of research in clinically relevant populations.

Original language	English
Pages (from-to)	71-84
Number of pages	14
Journal	Neuroscience and Biobehavioral Reviews
Volume	98
Early online date	3 Jan 2019
DOIs	https://doi.org/10.1016/j.neubiorev.2018.12.028
Publication status	Published - 1 Mar 2019

Keywords

Anxiety
Goal-conflict
Human behaviour
Individual differences
Neuroimaging
Threat response

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10.1016/j.neubiorev.2018.12.028

Brain activation during human_PATRICK_Accepted26December2018_GREEN AAM (CC BY-NC-ND)Accepted author manuscript, 490 KBLicence: CC BY-NC-ND

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title = "Brain activation during human defensive behaviour: a systematic review and preliminary meta-analysis",

abstract = "The neural underpinnings of defensive behaviour have implications for both basic research and clinical translation. This review systematically collates published research on neural response during simple avoidance of threat and approach-avoidance behaviour during goal-conflicting situations and presents an exploratory meta-analysis of available whole-brain data. Scopus, PsychInfo and Web of Science databases were searched for the period up to March 2018. 1,348 simple avoidance and 1,910 goal-conflict publications were initially identified; following review, 8 simple avoidance and 11 goal-conflict studies were included, with 5 datasets used in a preliminary meta-analysis. A move from forebrain-to-midbrain activation as threat becomes more pertinent was noted, indicating support for the Reinforcement Sensitivity Theory of behaviour and general compatibility with animal work. However, these findings were not reflected in the subsequent preliminary meta-analysis. This review highlights the considerable heterogeneity in currently available defensive behaviour paradigms and the lack of research in clinically relevant populations.",

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AU - Young, Allan H.

AU - Perkins, Adam M.

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Brain activation during human defensive behaviour: a systematic review and preliminary meta-analysis

Abstract

Keywords

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