Brain anatomy and ageing in non-demented adults with Down's syndrome: an in vivo MRI study

F. Beacher; E. Daly; A. Simmons; V. Prasher; R. Morris; C. Robinson; S. Lovestone; K. Murphy; D. G. M. Murphy

doi:10.1017/S0033291709990985

Brain anatomy and ageing in non-demented adults with Down's syndrome: an in vivo MRI study

F. Beacher, E. Daly, A. Simmons, V. Prasher, R. Morris, C. Robinson, S. Lovestone, K. Murphy, D. G. M. Murphy

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Background. People with Down's syndrome (DS) are at high risk for developing dementia in middle age. The biological basis for this is unknown. It has been proposed that non-demented adults with DS may undergo accelerated brain ageing. Method. We used volumetric magnetic resonance imaging (MRI) and manual tracing to compare brain anatomy and ageing in 39 non-demented adults with DS and 42 healthy controls. Results. Individuals with DS had significant differences in brain anatomy. Furthermore, individuals with DS had a significantly greater age-related reduction in volume of frontal, temporal and parietal lobes, and a significantly greater age-related increase in volume of peripheral cerebrospinal fluid (CSF). Conclusions. Non-demented adults with DS have differences in brain anatomy and 'accelerated' ageing of some brain regions. This may increase their risk for age-related cognitive decline and Alzheimer's disease (AD).

Original language	English
Pages (from-to)	611 - 619
Number of pages	9
Journal	Psychological Medicine
Volume	40
Issue number	4
DOIs	https://doi.org/10.1017/S0033291709990985
Publication status	Published - Apr 2010

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title = "Brain anatomy and ageing in non-demented adults with Down's syndrome: an in vivo MRI study",

abstract = "Background. People with Down's syndrome (DS) are at high risk for developing dementia in middle age. The biological basis for this is unknown. It has been proposed that non-demented adults with DS may undergo accelerated brain ageing. Method. We used volumetric magnetic resonance imaging (MRI) and manual tracing to compare brain anatomy and ageing in 39 non-demented adults with DS and 42 healthy controls. Results. Individuals with DS had significant differences in brain anatomy. Furthermore, individuals with DS had a significantly greater age-related reduction in volume of frontal, temporal and parietal lobes, and a significantly greater age-related increase in volume of peripheral cerebrospinal fluid (CSF). Conclusions. Non-demented adults with DS have differences in brain anatomy and 'accelerated' ageing of some brain regions. This may increase their risk for age-related cognitive decline and Alzheimer's disease (AD).",

author = "F. Beacher and E. Daly and A. Simmons and V. Prasher and R. Morris and C. Robinson and S. Lovestone and K. Murphy and Murphy, {D. G. M.}",

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doi = "10.1017/S0033291709990985",

language = "English",

volume = "40",

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TY - JOUR

T1 - Brain anatomy and ageing in non-demented adults with Down's syndrome: an in vivo MRI study

AU - Beacher, F.

AU - Daly, E.

AU - Simmons, A.

AU - Prasher, V.

AU - Morris, R.

AU - Robinson, C.

AU - Lovestone, S.

AU - Murphy, K.

AU - Murphy, D. G. M.

PY - 2010/4

Y1 - 2010/4

N2 - Background. People with Down's syndrome (DS) are at high risk for developing dementia in middle age. The biological basis for this is unknown. It has been proposed that non-demented adults with DS may undergo accelerated brain ageing. Method. We used volumetric magnetic resonance imaging (MRI) and manual tracing to compare brain anatomy and ageing in 39 non-demented adults with DS and 42 healthy controls. Results. Individuals with DS had significant differences in brain anatomy. Furthermore, individuals with DS had a significantly greater age-related reduction in volume of frontal, temporal and parietal lobes, and a significantly greater age-related increase in volume of peripheral cerebrospinal fluid (CSF). Conclusions. Non-demented adults with DS have differences in brain anatomy and 'accelerated' ageing of some brain regions. This may increase their risk for age-related cognitive decline and Alzheimer's disease (AD).

AB - Background. People with Down's syndrome (DS) are at high risk for developing dementia in middle age. The biological basis for this is unknown. It has been proposed that non-demented adults with DS may undergo accelerated brain ageing. Method. We used volumetric magnetic resonance imaging (MRI) and manual tracing to compare brain anatomy and ageing in 39 non-demented adults with DS and 42 healthy controls. Results. Individuals with DS had significant differences in brain anatomy. Furthermore, individuals with DS had a significantly greater age-related reduction in volume of frontal, temporal and parietal lobes, and a significantly greater age-related increase in volume of peripheral cerebrospinal fluid (CSF). Conclusions. Non-demented adults with DS have differences in brain anatomy and 'accelerated' ageing of some brain regions. This may increase their risk for age-related cognitive decline and Alzheimer's disease (AD).

U2 - 10.1017/S0033291709990985

DO - 10.1017/S0033291709990985

M3 - Article

SN - 1469-8978

VL - 40

SP - 611

EP - 619

JO - Psychological Medicine

JF - Psychological Medicine

IS - 4

ER -

Brain anatomy and ageing in non-demented adults with Down's syndrome: an in vivo MRI study

Abstract

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