Brain bioenergetics in murine models of scrapie using in vivo 31P magnetic resonance spectroscopy

Yuen-Li Chung, Steve C.R. Williams, James Hope, Jimmy D. Bell

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

THE bioenergetic status of the brain in scrapie mouse models was investigated during the late, clinical phase of the disease, by in vivo phosphorus magnetic resonance spectroscopy (MRS). The only significant change observed in the scrapie-infected mice compared with controls was an increase in intracellular brain pH (7.20+/-0.06 vs 7.10+/-0.05). No other changes in energetic metabolism were observed in the infected mice beside a trend in the decrease of phosphomonoester (PME) level, possibly associated with an alteration in glycolytic intermediates. This study showed that even in the presence of severe cellular vacuolation and microglia infiltrate, cerebral bioenergetic is maintained.

Original languageEnglish
Article numberN/A
Pages (from-to)1899-1901
Number of pages3
JournalNeuroreport
Volume10
Issue number9
Publication statusPublished - 23 Jun 1999

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