Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts

ENIGMA-MDD Working Group

doi:10.1016/j.biopsych.2021.03.015

Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts

ENIGMA-MDD Working Group

University of Queensland
1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. [2] Department of Urology, University of Southern California, Los Angeles, California, USA.
Amsterdam UMC
University of Melbourne Western Health, , Parkville, Melbourne, VIC, Australia; Australian Institute for Musculoskeletal Science (AIMSS) , The University of Melbourne and Western Health, St Albans, VIC, Australia; Melbourne School of Health Sciences The University of Melbourne , Parkville, Australia
Usher Institute, University of Edinburgh, Edinburgh, UK
Department of Psychosomatics and Psychotherapy, University Hospital Münster, Münster, Germany.
Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg Philipps‐Universität Marburg Marburg Germany
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Department of Biomedical Sciences, Florida State University, Tallahassee, FL, USA.
Queensland University of Technology QUT
Univ London, Birkbeck University London, University College London, University of London Royal Veterinary College, University of London, St Georges University London, Imperial College London, Kings College London, Royal Holloway University London, Queen Mary University London, Div Populat Hlth Sci & Educ
Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20246, Hamburg, Germany.
Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland, USA.
Division of Psychiatry and Institute of Cognitive Neuroscience,University College London and Institute of Psychiatry, Psychology and Neuroscience, King's College London and South London and Maudsley NHS Foundation Trust,UK.
1Department of Hepatology, Imperial College London, London, UK. 2Institute of Liver Studies at King's College School of Medicine at King's College Hospital, London, UK. 3Institute of Human Health and Performance, University College London, London, UK. 4Department of Asthma Allergy and Lung Biology, King's College London, London, UK. 5Division of Critical Care Medicine, University of Alberta, Edmonton, Canada.
Curtin University
Research Department of Epidemiology and Public Health, University College London, UK; School of Psychology, University of East London, London, UK.
University of Ioannina School of Medicine; Stanford Prevention Research Center; Stanford University School of Medicine
German Center for Neurodegenerative Disease
Institute for Musculoskeletal Health, The University of Sydney and Sydney Local Health District , Sydney, Australia
Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA.; Department of Radiology, University of California, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, CA, USA.; Department of Psychiatry, University of California, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, CA, USA.
Department of Epileptology, University Hospital Bonn, Bonn, Germany
University of Calgary
Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Department of Computational Biology - USR 3756 CNRS), Institut Pasteur, Paris, France; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard Medical School, Boston, MA, USA.
Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore; Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of Singapore Graduate Medical School, Singapore 169857, Singapore.

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD Working Group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior.

METHODS: Here, we pooled data from 18 international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy control subjects and 6448 people with depression, of whom 694 had attempted suicide). We compared regional cortical thickness and surface area and measures of subcortical, lateral ventricular, and intracranial volumes between suicide attempters, clinical control subjects (nonattempters with depression), and healthy control subjects.

RESULTS: We identified 25 regions of interest with statistically significant (false discovery rate < .05) differences between groups. Post hoc examinations identified neuroimaging markers associated with suicide attempt including smaller volumes of the left and right thalamus and the right pallidum and lower surface area of the left inferior parietal lobe.

CONCLUSIONS: This study addresses the lack of replicability and consistency in several previously published neuroimaging studies of suicide attempt and further demonstrates the need for well-powered samples and collaborative efforts. Our results highlight the potential involvement of the thalamus, a structure viewed historically as a passive gateway in the brain, and the pallidum, a region linked to reward response and positive affect. Future functional and connectivity studies of suicidal behaviors may focus on understanding how these regions relate to the neurobiological mechanisms of suicide attempt risk.

Original language	English
Pages (from-to)	243-252
Number of pages	10
Journal	Biological psychiatry
Volume	90
Issue number	4
DOIs	https://doi.org/10.1016/j.biopsych.2021.03.015
Publication status	Published - 15 Aug 2021

Keywords

Brain/diagnostic imaging
Depressive Disorder, Major/diagnostic imaging
Humans
Magnetic Resonance Imaging
Neuroimaging
Suicide, Attempted

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.biopsych.2021.03.015

Cite this

@article{23f0a5fde37447f3b58b4251df66b458,

title = "Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts",

abstract = "BACKGROUND: Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD Working Group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior.METHODS: Here, we pooled data from 18 international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy control subjects and 6448 people with depression, of whom 694 had attempted suicide). We compared regional cortical thickness and surface area and measures of subcortical, lateral ventricular, and intracranial volumes between suicide attempters, clinical control subjects (nonattempters with depression), and healthy control subjects.RESULTS: We identified 25 regions of interest with statistically significant (false discovery rate < .05) differences between groups. Post hoc examinations identified neuroimaging markers associated with suicide attempt including smaller volumes of the left and right thalamus and the right pallidum and lower surface area of the left inferior parietal lobe.CONCLUSIONS: This study addresses the lack of replicability and consistency in several previously published neuroimaging studies of suicide attempt and further demonstrates the need for well-powered samples and collaborative efforts. Our results highlight the potential involvement of the thalamus, a structure viewed historically as a passive gateway in the brain, and the pallidum, a region linked to reward response and positive affect. Future functional and connectivity studies of suicidal behaviors may focus on understanding how these regions relate to the neurobiological mechanisms of suicide attempt risk.",

keywords = "Brain/diagnostic imaging, Depressive Disorder, Major/diagnostic imaging, Humans, Magnetic Resonance Imaging, Neuroimaging, Suicide, Attempted",

author = "{ENIGMA-MDD Working Group} and Campos, {Adrian I} and Thompson, {Paul M} and Veltman, {Dick J} and Elena Pozzi and {van Veltzen}, {Laura S} and Neda Jahanshad and Adams, {Mark J} and Baune, {Bernhard T} and Klaus Berger and Katharina Brosch and Robin B{\"u}low and Connolly, {Colm G} and Udo Dannlowski and Davey, {Christopher G} and {de Zubicaray}, {Greig I} and Danai Dima and Tracy Erwin-Grabner and Evans, {Jennifer W} and Fu, {Cynthia H Y} and Gotlib, {Ian H} and Roberto Goya-Maldonado and Grabe, {Hans J} and Dominik Grotegerd and Harris, {Matthew A} and Harrison, {Ben J} and Hatton, {Sean N} and Marco Hermesdorf and Hickie, {Ian B} and Ho, {Tiffany C} and Tilo Kircher and Axel Krug and Jim Lagopoulos and Hannah Lemke and Katie McMahon and MacMaster, {Frank P} and Martin, {Nicholas G} and McIntosh, {Andrew M} and Medland, {Sarah E} and Susanne Meinert and Tina Meller and Igor Nenadic and Nils Opel and Ronny Redlich and Liesbeth Reneman and Jonathan Repple and Sacchet, {Matthew D} and Simon Schmitt and Anouk Schrantee and Kang Sim and Aditya Singh",

year = "2021",

month = aug,

day = "15",

doi = "10.1016/j.biopsych.2021.03.015",

language = "English",

volume = "90",

pages = "243--252",

journal = "Biological psychiatry",

issn = "0006-3223",

publisher = "Elsevier",

number = "4",

}

TY - JOUR

T1 - Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts

AU - ENIGMA-MDD Working Group

AU - Campos, Adrian I

AU - Thompson, Paul M

AU - Veltman, Dick J

AU - Pozzi, Elena

AU - van Veltzen, Laura S

AU - Jahanshad, Neda

AU - Adams, Mark J

AU - Baune, Bernhard T

AU - Berger, Klaus

AU - Brosch, Katharina

AU - Bülow, Robin

AU - Connolly, Colm G

AU - Dannlowski, Udo

AU - Davey, Christopher G

AU - de Zubicaray, Greig I

AU - Dima, Danai

AU - Erwin-Grabner, Tracy

AU - Evans, Jennifer W

AU - Fu, Cynthia H Y

AU - Gotlib, Ian H

AU - Goya-Maldonado, Roberto

AU - Grabe, Hans J

AU - Grotegerd, Dominik

AU - Harris, Matthew A

AU - Harrison, Ben J

AU - Hatton, Sean N

AU - Hermesdorf, Marco

AU - Hickie, Ian B

AU - Ho, Tiffany C

AU - Kircher, Tilo

AU - Krug, Axel

AU - Lagopoulos, Jim

AU - Lemke, Hannah

AU - McMahon, Katie

AU - MacMaster, Frank P

AU - Martin, Nicholas G

AU - McIntosh, Andrew M

AU - Medland, Sarah E

AU - Meinert, Susanne

AU - Meller, Tina

AU - Nenadic, Igor

AU - Opel, Nils

AU - Redlich, Ronny

AU - Reneman, Liesbeth

AU - Repple, Jonathan

AU - Sacchet, Matthew D

AU - Schmitt, Simon

AU - Schrantee, Anouk

AU - Sim, Kang

AU - Singh, Aditya

PY - 2021/8/15

Y1 - 2021/8/15

N2 - BACKGROUND: Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD Working Group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior.METHODS: Here, we pooled data from 18 international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy control subjects and 6448 people with depression, of whom 694 had attempted suicide). We compared regional cortical thickness and surface area and measures of subcortical, lateral ventricular, and intracranial volumes between suicide attempters, clinical control subjects (nonattempters with depression), and healthy control subjects.RESULTS: We identified 25 regions of interest with statistically significant (false discovery rate < .05) differences between groups. Post hoc examinations identified neuroimaging markers associated with suicide attempt including smaller volumes of the left and right thalamus and the right pallidum and lower surface area of the left inferior parietal lobe.CONCLUSIONS: This study addresses the lack of replicability and consistency in several previously published neuroimaging studies of suicide attempt and further demonstrates the need for well-powered samples and collaborative efforts. Our results highlight the potential involvement of the thalamus, a structure viewed historically as a passive gateway in the brain, and the pallidum, a region linked to reward response and positive affect. Future functional and connectivity studies of suicidal behaviors may focus on understanding how these regions relate to the neurobiological mechanisms of suicide attempt risk.

AB - BACKGROUND: Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD Working Group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior.METHODS: Here, we pooled data from 18 international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy control subjects and 6448 people with depression, of whom 694 had attempted suicide). We compared regional cortical thickness and surface area and measures of subcortical, lateral ventricular, and intracranial volumes between suicide attempters, clinical control subjects (nonattempters with depression), and healthy control subjects.RESULTS: We identified 25 regions of interest with statistically significant (false discovery rate < .05) differences between groups. Post hoc examinations identified neuroimaging markers associated with suicide attempt including smaller volumes of the left and right thalamus and the right pallidum and lower surface area of the left inferior parietal lobe.CONCLUSIONS: This study addresses the lack of replicability and consistency in several previously published neuroimaging studies of suicide attempt and further demonstrates the need for well-powered samples and collaborative efforts. Our results highlight the potential involvement of the thalamus, a structure viewed historically as a passive gateway in the brain, and the pallidum, a region linked to reward response and positive affect. Future functional and connectivity studies of suicidal behaviors may focus on understanding how these regions relate to the neurobiological mechanisms of suicide attempt risk.

KW - Brain/diagnostic imaging

KW - Depressive Disorder, Major/diagnostic imaging

KW - Humans

KW - Magnetic Resonance Imaging

KW - Neuroimaging

KW - Suicide, Attempted

U2 - 10.1016/j.biopsych.2021.03.015

DO - 10.1016/j.biopsych.2021.03.015

M3 - Article

C2 - 34172278

SN - 0006-3223

VL - 90

SP - 243

EP - 252

JO - Biological psychiatry

JF - Biological psychiatry

IS - 4

ER -

Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this