Brain damage of the preterm infant: new insights into the role of inflammation

Juliette Van Steenwinckel; Anne-Laure Schang; Stéphanie Sigaut; Vibol Chhor; Vincent Degos; Henrik Hagberg; Olivier Baud; Bobbi Fleiss; Pierre Gressens

doi:10.1042/BST20130284

Brain damage of the preterm infant: new insights into the role of inflammation

Juliette Van Steenwinckel, Anne-Laure Schang, Stéphanie Sigaut, Vibol Chhor, Vincent Degos, Henrik Hagberg, Olivier Baud, Bobbi Fleiss, Pierre Gressens

Inserm, U1141, F-75019 Paris, France.

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Epidemiological studies have shown a strong association between perinatal infection/inflammation and brain damage in preterm infants and/or neurological handicap in survivors. Experimental studies have shown a causal effect of infection/inflammation on perinatal brain damage. Infection including inflammatory factors can disrupt programmes of brain development and, in particular, induce death and/or blockade of oligodendrocyte maturation, leading to myelin defects. Alternatively, in the so-called multiple-hit hypothesis, infection/inflammation can act as predisposing factors, making the brain more susceptible to a second stress (sensitization process), such as hypoxic-ischaemic or excitotoxic insults. Epidemiological data also suggest that perinatal exposure to inflammatory factors could predispose to long-term diseases including psychiatric disorders.

Original language	English
Article number	N/A
Pages (from-to)	557-563
Number of pages	7
Journal	Biochemical Society Transactions
Volume	42
Issue number	2
DOIs	https://doi.org/10.1042/BST20130284
Publication status	Published - 1 Apr 2014

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abstract = "Epidemiological studies have shown a strong association between perinatal infection/inflammation and brain damage in preterm infants and/or neurological handicap in survivors. Experimental studies have shown a causal effect of infection/inflammation on perinatal brain damage. Infection including inflammatory factors can disrupt programmes of brain development and, in particular, induce death and/or blockade of oligodendrocyte maturation, leading to myelin defects. Alternatively, in the so-called multiple-hit hypothesis, infection/inflammation can act as predisposing factors, making the brain more susceptible to a second stress (sensitization process), such as hypoxic-ischaemic or excitotoxic insults. Epidemiological data also suggest that perinatal exposure to inflammatory factors could predispose to long-term diseases including psychiatric disorders.",

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AU - Degos, Vincent

AU - Hagberg, Henrik

AU - Baud, Olivier

AU - Fleiss, Bobbi

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Brain damage of the preterm infant: new insights into the role of inflammation

Abstract

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