Brain Insulin Resistance

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


Metabolic syndrome and insulin resistance are usually described in terms of the insulin responsiveness of peripheral tissues – liver, muscle, fat – but there is a growing body of evidence for brain insulin responsiveness – and resistance – which is regionally variant. Insulin resistance in the brain pathways controlling appetite, food ingestion and cessation of food ingestion may be implicated in the pathogenesis of obesity and its co-morbidities. The role of insulin in cognitive function is also being elucidated, with neuroimaging and biochemical data accumulating to support the epidemiological evidence linking insulin resistance and type 2 diabetes with dementia. Inter-individual differences in brain insulin responsiveness may help explain differences in individual propensity to two of the major health scourges of modern living: obesity and cognitive decline and offer an exciting opportunity for potential new preventive strategies.
Original languageEnglish
Title of host publicationThe Metabolic Syndrome
EditorsChristopher Byrne, Sarah Wild
Place of PublicationChichester, West Sussex
ISBN (Electronic)9781444347319
ISBN (Print)9781444336580
Publication statusPublished - Jul 2011


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