Brain PET Imaging in the Presurgical Evaluation of Drug-Resistant Focal Epilepsy

Anthime Flaus; Eric Guedj; Tatiana Horowitz; Franck Semah; Antoine Verger; Alexander Hammers

doi:10.1016/j.cpet.2024.09.008

Brain PET Imaging in the Presurgical Evaluation of Drug-Resistant Focal Epilepsy

Anthime Flaus, Eric Guedj, Tatiana Horowitz, Franck Semah, Antoine Verger, Alexander Hammers

PET Imaging Centre Facility

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

Presurgical evaluation aims to localize the seizure onset zone (SOZ) for a tailored resection. Interictal [ 18F]fluorodeoxyglucose PET is now an established test to lateralize and/or localize the SOZ, particularly if MR imaging is negative or if the noninvasive assessment shows discrepancies. PET can show hypometabolic areas associated with SOZ and the potential altered metabolic brain networks. It is very sensitive, and this is increased if images are read coregistered to the patient's MR imaging. PET hypometabolic intensity and pattern show prognostic value.

Original language	English
Pages (from-to)	57-66
Number of pages	10
Journal	PET Clinics
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.cpet.2024.09.008
Publication status	Published - Jan 2025

Keywords

Humans
Brain/diagnostic imaging
Drug Resistant Epilepsy/diagnostic imaging
Epilepsies, Partial/diagnostic imaging
Fluorodeoxyglucose F18
Magnetic Resonance Imaging/methods
Positron-Emission Tomography/methods
Preoperative Care/methods
Radiopharmaceuticals

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10.1016/j.cpet.2024.09.008

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title = "Brain PET Imaging in the Presurgical Evaluation of Drug-Resistant Focal Epilepsy",

abstract = "Presurgical evaluation aims to localize the seizure onset zone (SOZ) for a tailored resection. Interictal [ 18F]fluorodeoxyglucose PET is now an established test to lateralize and/or localize the SOZ, particularly if MR imaging is negative or if the noninvasive assessment shows discrepancies. PET can show hypometabolic areas associated with SOZ and the potential altered metabolic brain networks. It is very sensitive, and this is increased if images are read coregistered to the patient's MR imaging. PET hypometabolic intensity and pattern show prognostic value. ",

keywords = "Humans, Brain/diagnostic imaging, Drug Resistant Epilepsy/diagnostic imaging, Epilepsies, Partial/diagnostic imaging, Fluorodeoxyglucose F18, Magnetic Resonance Imaging/methods, Positron-Emission Tomography/methods, Preoperative Care/methods, Radiopharmaceuticals",

author = "Anthime Flaus and Eric Guedj and Tatiana Horowitz and Franck Semah and Antoine Verger and Alexander Hammers",

year = "2025",

month = jan,

doi = "10.1016/j.cpet.2024.09.008",

language = "English",

volume = "20",

pages = "57--66",

journal = "PET Clinics",

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T1 - Brain PET Imaging in the Presurgical Evaluation of Drug-Resistant Focal Epilepsy

AU - Flaus, Anthime

AU - Guedj, Eric

AU - Horowitz, Tatiana

AU - Semah, Franck

AU - Verger, Antoine

AU - Hammers, Alexander

PY - 2025/1

Y1 - 2025/1

N2 - Presurgical evaluation aims to localize the seizure onset zone (SOZ) for a tailored resection. Interictal [ 18F]fluorodeoxyglucose PET is now an established test to lateralize and/or localize the SOZ, particularly if MR imaging is negative or if the noninvasive assessment shows discrepancies. PET can show hypometabolic areas associated with SOZ and the potential altered metabolic brain networks. It is very sensitive, and this is increased if images are read coregistered to the patient's MR imaging. PET hypometabolic intensity and pattern show prognostic value.

AB - Presurgical evaluation aims to localize the seizure onset zone (SOZ) for a tailored resection. Interictal [ 18F]fluorodeoxyglucose PET is now an established test to lateralize and/or localize the SOZ, particularly if MR imaging is negative or if the noninvasive assessment shows discrepancies. PET can show hypometabolic areas associated with SOZ and the potential altered metabolic brain networks. It is very sensitive, and this is increased if images are read coregistered to the patient's MR imaging. PET hypometabolic intensity and pattern show prognostic value.

KW - Humans

KW - Brain/diagnostic imaging

KW - Drug Resistant Epilepsy/diagnostic imaging

KW - Epilepsies, Partial/diagnostic imaging

KW - Fluorodeoxyglucose F18

KW - Magnetic Resonance Imaging/methods

KW - Positron-Emission Tomography/methods

KW - Preoperative Care/methods

KW - Radiopharmaceuticals

U2 - 10.1016/j.cpet.2024.09.008

DO - 10.1016/j.cpet.2024.09.008

M3 - Review article

C2 - 39426849

SN - 1556-8598

VL - 20

SP - 57

EP - 66

JO - PET Clinics

JF - PET Clinics

IS - 1

ER -

Brain PET Imaging in the Presurgical Evaluation of Drug-Resistant Focal Epilepsy

Abstract

Keywords

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