Brain white matter structural connectivity of trauma and trauma-related dissociation disorders and symptoms

TY - JOUR

T1 - Brain white matter structural connectivity of trauma and trauma-related dissociation disorders and symptoms

AU - Dimitrova, Lora I

AU - Chalavi, Sima

AU - Vissia, Eline M

AU - Barker, Gareth J

AU - Perez, David L

AU - Veltman, Dick J

AU - Diez, Ibai

AU - Reinders, Antje A T S

N1 - Copyright © 2025. Published by Elsevier B.V.

PY - 2025/1/31

Y1 - 2025/1/31

N2 - BACKGROUND: Experiencing repeated childhood traumatisation impacts brain structure and function in individuals with dissociative identity disorder (DID) and post-traumatic stress disorder (PTSD). Quantitative grey matter neuroimaging research has shown aberrant volumes in traumatised individuals, however studies examining white matter are sparse, particularly for DID. The present study aims to examine white matter alterations of people with trauma-related disorders.METHODS: Sixty-five female participants were included in this study: 33 diagnosed with a trauma-related disorder, namely 17 with DID and 16 with PTSD, and 32 healthy control (HC) participants. All participants underwent diffusion tensor imaging (DTI) and completed dissociation and traumatisation self-report measures. White matter integrity was characterised using voxel-based analysis (VBA), with network lesion mapping used to identify the implicated grey matter end points of the VBA findings.RESULTS: Between-group VBA comparisons showed reduced fractional anisotropy (FA) for participants with DID compared to HCs in bilateral pallidum (implicating striatal projections to pre/post central gyri), midbrain, and pontocerebellar white matter. Compared to those with PTSD, DID subjects showed increased FA in the right internal capsule and right temporal areas (predominantly implicating the inferior longitudinal fasciculus). Across DID and PTSD subjects, FA values within the aforementioned findings negatively correlated with depersonalisation, psychoform and somatoform dissociation, and/or traumatisation scores.CONCLUSIONS: Our DTI findings indicate markedly differential white matter integrity in DID compared to PTSD and HCs. This provides valuable mechanistic insights regarding a role for aberrant white matter structural integrity in traumatised female individuals with DID.

AB - BACKGROUND: Experiencing repeated childhood traumatisation impacts brain structure and function in individuals with dissociative identity disorder (DID) and post-traumatic stress disorder (PTSD). Quantitative grey matter neuroimaging research has shown aberrant volumes in traumatised individuals, however studies examining white matter are sparse, particularly for DID. The present study aims to examine white matter alterations of people with trauma-related disorders.METHODS: Sixty-five female participants were included in this study: 33 diagnosed with a trauma-related disorder, namely 17 with DID and 16 with PTSD, and 32 healthy control (HC) participants. All participants underwent diffusion tensor imaging (DTI) and completed dissociation and traumatisation self-report measures. White matter integrity was characterised using voxel-based analysis (VBA), with network lesion mapping used to identify the implicated grey matter end points of the VBA findings.RESULTS: Between-group VBA comparisons showed reduced fractional anisotropy (FA) for participants with DID compared to HCs in bilateral pallidum (implicating striatal projections to pre/post central gyri), midbrain, and pontocerebellar white matter. Compared to those with PTSD, DID subjects showed increased FA in the right internal capsule and right temporal areas (predominantly implicating the inferior longitudinal fasciculus). Across DID and PTSD subjects, FA values within the aforementioned findings negatively correlated with depersonalisation, psychoform and somatoform dissociation, and/or traumatisation scores.CONCLUSIONS: Our DTI findings indicate markedly differential white matter integrity in DID compared to PTSD and HCs. This provides valuable mechanistic insights regarding a role for aberrant white matter structural integrity in traumatised female individuals with DID.

UR - http://www.scopus.com/inward/record.url?scp=85217039308&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2025.116383

DO - 10.1016/j.psychres.2025.116383

M3 - Article

C2 - 39921931

SN - 0165-1781

VL - 346

SP - 116383

JO - Psychiatry Research

JF - Psychiatry Research

M1 - 116383

ER -