Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors

R. Cooke; M. E. Jones; D. Cunningham; S. J. Falk; D. Gilson; B. W. Hancock; Sarah Harris; A. Horwich; P. J. Hoskin; T. Illidge; D. C. Linch; T. A. Lister; H. H. Lucraft; J. A. Radford; A. M. Stevens; I. Syndikus; M. V. Williams; A. J. Swerdlow; England Wales Hodgkin Lymphoma

doi:10.1038/bjc.2013.219

Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors

R. Cooke^*, M. E. Jones, D. Cunningham, S. J. Falk, D. Gilson, B. W. Hancock, Sarah Harris, A. Horwich, P. J. Hoskin, T. Illidge, D. C. Linch, T. A. Lister, H. H. Lucraft, J. A. Radford, A. M. Stevens, I. Syndikus, M. V. Williams, A. J. Swerdlow, England Wales Hodgkin Lymphoma

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Background: Women treated with supradiaphragmatic radiotherapy (sRT) for Hodgkin lymphoma (HL) at young ages have a substantially increased breast cancer risk. Little is known about how menarcheal and reproductive factors modify this risk.

Methods: We examined the effects of menarcheal age, pregnancy, and menopausal age on breast cancer risk following sRT in case-control data from questionnaires completed by 2497 women from a cohort of 5002 treated with sRT for HL at ages

Results: Two-hundred and sixty women had been diagnosed with breast cancer. Breast cancer risk was significantly increased in patients treated within 6 months of menarche (odds ratio (OR) 5.52, 95% confidence interval (CI) (1.97-15.46)), and increased significantly with proximity of sRT to menarche (P-trend

Conclusion: In summary, this paper shows for the first time that sRT close to menarche substantially increases breast cancer risk. Careful consideration should be given to follow-up of these women, and to measures that might reduce their future breast cancer risk.

Original language	English
Pages (from-to)	2399-2406
Number of pages	8
Journal	BJC: British Journal of Cancer
Volume	108
Issue number	11
DOIs	https://doi.org/10.1038/bjc.2013.219
Publication status	Published - 11 Jun 2013

Keywords

Hodgkin lymphoma
breast cancer
supradiaphragmatic radiotherapy
MAMMOGRAPHIC DENSITY
PARENCHYMAL PATTERNS
UNITED-STATES
YOUNG-WOMEN
DISEASE
AGE
RADIATION
MENARCHE
COHORT
CHILDHOOD

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/bjc.2013.219

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Cooke, R., Jones, M. E., Cunningham, D., Falk, S. J., Gilson, D., Hancock, B. W., Harris, S., Horwich, A., Hoskin, P. J., Illidge, T., Linch, D. C., Lister, T. A., Lucraft, H. H., Radford, J. A., Stevens, A. M., Syndikus, I., Williams, M. V., Swerdlow, A. J., & England Wales Hodgkin Lymphoma (2013). Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors. BJC: British Journal of Cancer, 108(11), 2399-2406. https://doi.org/10.1038/bjc.2013.219

@article{d7bf583490d44a72ab61e10c0d5ddb2b,

title = "Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors",

abstract = "Background: Women treated with supradiaphragmatic radiotherapy (sRT) for Hodgkin lymphoma (HL) at young ages have a substantially increased breast cancer risk. Little is known about how menarcheal and reproductive factors modify this risk.Methods: We examined the effects of menarcheal age, pregnancy, and menopausal age on breast cancer risk following sRT in case-control data from questionnaires completed by 2497 women from a cohort of 5002 treated with sRT for HL at ages Results: Two-hundred and sixty women had been diagnosed with breast cancer. Breast cancer risk was significantly increased in patients treated within 6 months of menarche (odds ratio (OR) 5.52, 95% confidence interval (CI) (1.97-15.46)), and increased significantly with proximity of sRT to menarche (P-trendConclusion: In summary, this paper shows for the first time that sRT close to menarche substantially increases breast cancer risk. Careful consideration should be given to follow-up of these women, and to measures that might reduce their future breast cancer risk.",

keywords = "Hodgkin lymphoma, breast cancer, supradiaphragmatic radiotherapy, MAMMOGRAPHIC DENSITY, PARENCHYMAL PATTERNS, UNITED-STATES, YOUNG-WOMEN, DISEASE, AGE, RADIATION, MENARCHE, COHORT, CHILDHOOD",

author = "R. Cooke and Jones, {M. E.} and D. Cunningham and Falk, {S. J.} and D. Gilson and Hancock, {B. W.} and Sarah Harris and A. Horwich and Hoskin, {P. J.} and T. Illidge and Linch, {D. C.} and Lister, {T. A.} and Lucraft, {H. H.} and Radford, {J. A.} and Stevens, {A. M.} and I. Syndikus and Williams, {M. V.} and Swerdlow, {A. J.} and {England Wales Hodgkin Lymphoma}",

year = "2013",

month = jun,

day = "11",

doi = "10.1038/bjc.2013.219",

language = "English",

volume = "108",

pages = "2399--2406",

journal = "BJC: British Journal of Cancer",

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Cooke, R, Jones, ME, Cunningham, D, Falk, SJ, Gilson, D, Hancock, BW, Harris, S, Horwich, A, Hoskin, PJ, Illidge, T, Linch, DC, Lister, TA, Lucraft, HH, Radford, JA, Stevens, AM, Syndikus, I, Williams, MV, Swerdlow, AJ & England Wales Hodgkin Lymphoma 2013, 'Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors', BJC: British Journal of Cancer, vol. 108, no. 11, pp. 2399-2406. https://doi.org/10.1038/bjc.2013.219

TY - JOUR

T1 - Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors

AU - Cooke, R.

AU - Jones, M. E.

AU - Cunningham, D.

AU - Falk, S. J.

AU - Gilson, D.

AU - Hancock, B. W.

AU - Harris, Sarah

AU - Horwich, A.

AU - Hoskin, P. J.

AU - Illidge, T.

AU - Linch, D. C.

AU - Lister, T. A.

AU - Lucraft, H. H.

AU - Radford, J. A.

AU - Stevens, A. M.

AU - Syndikus, I.

AU - Williams, M. V.

AU - Swerdlow, A. J.

AU - England Wales Hodgkin Lymphoma

PY - 2013/6/11

Y1 - 2013/6/11

N2 - Background: Women treated with supradiaphragmatic radiotherapy (sRT) for Hodgkin lymphoma (HL) at young ages have a substantially increased breast cancer risk. Little is known about how menarcheal and reproductive factors modify this risk.Methods: We examined the effects of menarcheal age, pregnancy, and menopausal age on breast cancer risk following sRT in case-control data from questionnaires completed by 2497 women from a cohort of 5002 treated with sRT for HL at ages Results: Two-hundred and sixty women had been diagnosed with breast cancer. Breast cancer risk was significantly increased in patients treated within 6 months of menarche (odds ratio (OR) 5.52, 95% confidence interval (CI) (1.97-15.46)), and increased significantly with proximity of sRT to menarche (P-trendConclusion: In summary, this paper shows for the first time that sRT close to menarche substantially increases breast cancer risk. Careful consideration should be given to follow-up of these women, and to measures that might reduce their future breast cancer risk.

AB - Background: Women treated with supradiaphragmatic radiotherapy (sRT) for Hodgkin lymphoma (HL) at young ages have a substantially increased breast cancer risk. Little is known about how menarcheal and reproductive factors modify this risk.Methods: We examined the effects of menarcheal age, pregnancy, and menopausal age on breast cancer risk following sRT in case-control data from questionnaires completed by 2497 women from a cohort of 5002 treated with sRT for HL at ages Results: Two-hundred and sixty women had been diagnosed with breast cancer. Breast cancer risk was significantly increased in patients treated within 6 months of menarche (odds ratio (OR) 5.52, 95% confidence interval (CI) (1.97-15.46)), and increased significantly with proximity of sRT to menarche (P-trendConclusion: In summary, this paper shows for the first time that sRT close to menarche substantially increases breast cancer risk. Careful consideration should be given to follow-up of these women, and to measures that might reduce their future breast cancer risk.

KW - Hodgkin lymphoma

KW - breast cancer

KW - supradiaphragmatic radiotherapy

KW - MAMMOGRAPHIC DENSITY

KW - PARENCHYMAL PATTERNS

KW - UNITED-STATES

KW - YOUNG-WOMEN

KW - DISEASE

KW - AGE

KW - RADIATION

KW - MENARCHE

KW - COHORT

KW - CHILDHOOD

U2 - 10.1038/bjc.2013.219

DO - 10.1038/bjc.2013.219

M3 - Article

SN - 0007-0920

VL - 108

SP - 2399

EP - 2406

JO - BJC: British Journal of Cancer

JF - BJC: British Journal of Cancer

IS - 11

ER -

Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors

Abstract

Keywords

UN SDGs

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