Breast imaging using the Twente Photoacoustic Mammoscope (PAM): New clinical measurements

TY - CHAP

T1 - Breast imaging using the Twente Photoacoustic Mammoscope (PAM)

T2 - European Conference on Biomedical Optics, ECBO 2011

AU - Heijblom, Michelle

AU - Piras, Daniele

AU - Tije, Ellen Ten

AU - Xia, Wenfeng

AU - Van Hespen, Johan

AU - Klaase, Joost

AU - Van Den Engh, Frank

AU - Van Leeuwen, Ton

AU - Steenbergen, Wiendelt

AU - Manohar, Srirang

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Worldwide, yearly about 450,000 women die from the consequences of breast cancer. Current imaging modalities are not optimal in discriminating benign from malignant tissue. Visualizing the malignancy-associated increased hemoglobin concentration might significantly improve early diagnosis of breast cancer. Since photoacoustic imaging can visualize hemoglobin in tissue with optical contrast and ultrasound-like resolution, it is potentially an ideal method for early breast cancer imaging. The Twente Photoacoustic Mammoscope (PAM) has been developed specifically for breast imaging. Recently, a large clinical study has been started in the Medisch Spectrum Twente in Oldenzaal using PAM. In PAM, the breast is slightly compressed between a window for laser light illumination and a flat array ultrasound detector. The measurements are performed using a Q-switched Nd:YAG laser, pulsed at 1064 nm and a 1 MHz unfocused ultrasound detector array. Three-dimensional data are reconstructed using a delay and sum reconstruction algorithm. Those reconstructed images are compared with conventional imaging and histopathology. In the first phase of the study 12 patients with a malignant lesion and 2 patients with a benign cyst have been measured. The results are used to guide developments in photoacoustic mammography in order to pave the way towards an optimal technique for early diagnosis of breast cancer.

AB - Worldwide, yearly about 450,000 women die from the consequences of breast cancer. Current imaging modalities are not optimal in discriminating benign from malignant tissue. Visualizing the malignancy-associated increased hemoglobin concentration might significantly improve early diagnosis of breast cancer. Since photoacoustic imaging can visualize hemoglobin in tissue with optical contrast and ultrasound-like resolution, it is potentially an ideal method for early breast cancer imaging. The Twente Photoacoustic Mammoscope (PAM) has been developed specifically for breast imaging. Recently, a large clinical study has been started in the Medisch Spectrum Twente in Oldenzaal using PAM. In PAM, the breast is slightly compressed between a window for laser light illumination and a flat array ultrasound detector. The measurements are performed using a Q-switched Nd:YAG laser, pulsed at 1064 nm and a 1 MHz unfocused ultrasound detector array. Three-dimensional data are reconstructed using a delay and sum reconstruction algorithm. Those reconstructed images are compared with conventional imaging and histopathology. In the first phase of the study 12 patients with a malignant lesion and 2 patients with a benign cyst have been measured. The results are used to guide developments in photoacoustic mammography in order to pave the way towards an optimal technique for early diagnosis of breast cancer.

KW - Angiogenesis

KW - Breast cancer

KW - Mammography

KW - Near-infrared light

KW - Optical imaging

KW - Photoacoustic imaging

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=84893599542&partnerID=8YFLogxK

M3 - Conference paper

AN - SCOPUS:84893599542

SN - 9780819486837

BT - European Conference on Biomedical Optics, ECBO 2011

Y2 - 22 May 2011 through 26 May 2011

ER -