Bridging the nanoscopy-immunology gap

Michael Shannon; Dylan M. Owen

doi:10.3389/fphy.2018.00157

Bridging the nanoscopy-immunology gap

Michael Shannon, Dylan M. Owen^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Bridging the gap between traditional immunology and nanoscale biophysics has proved more difficult than originally thought. For cell biology applications however, super-resolution microscopy has already facilitated considerable advances. From neuronal segmentation to nuclear pores and 3D focal adhesion structure-nanoscopy has begun to illuminate links between nanoscale organization and function. With immunology, the explanation must go further, relating nanoscale biophysical phenomena to the manifestation of specific diseases, or the altered activity of specific immune cell types in a bodily compartment. What follows is a summary of how nanoscopy has elucidated single cell immunological function, and what might be achieved in the future to link quantifiable, nanoscale, biophysical phenomena with cell and whole tissue functionality. We explore where the gaps in our understanding occur, and how they might be addressed.

Original language	English
Article number	157
Journal	Frontiers in Physics
Volume	6
Issue number	JAN
DOIs	https://doi.org/10.3389/fphy.2018.00157
Publication status	Published - 24 Jan 2019

Keywords

Immunology
Nanoscopy
SMLM
Super-resolution
T cells

Access to Document

10.3389/fphy.2018.00157

Cite this

@article{7956d33246c44cdbbc3a1334f6cdedc2,

title = "Bridging the nanoscopy-immunology gap",

abstract = "Bridging the gap between traditional immunology and nanoscale biophysics has proved more difficult than originally thought. For cell biology applications however, super-resolution microscopy has already facilitated considerable advances. From neuronal segmentation to nuclear pores and 3D focal adhesion structure-nanoscopy has begun to illuminate links between nanoscale organization and function. With immunology, the explanation must go further, relating nanoscale biophysical phenomena to the manifestation of specific diseases, or the altered activity of specific immune cell types in a bodily compartment. What follows is a summary of how nanoscopy has elucidated single cell immunological function, and what might be achieved in the future to link quantifiable, nanoscale, biophysical phenomena with cell and whole tissue functionality. We explore where the gaps in our understanding occur, and how they might be addressed.",

keywords = "Immunology, Nanoscopy, SMLM, Super-resolution, T cells",

author = "Michael Shannon and Owen, {Dylan M.}",

year = "2019",

month = jan,

day = "24",

doi = "10.3389/fphy.2018.00157",

language = "English",

volume = "6",

journal = "Frontiers in Physics",

number = "JAN",

}

TY - JOUR

T1 - Bridging the nanoscopy-immunology gap

AU - Shannon, Michael

AU - Owen, Dylan M.

PY - 2019/1/24

Y1 - 2019/1/24

N2 - Bridging the gap between traditional immunology and nanoscale biophysics has proved more difficult than originally thought. For cell biology applications however, super-resolution microscopy has already facilitated considerable advances. From neuronal segmentation to nuclear pores and 3D focal adhesion structure-nanoscopy has begun to illuminate links between nanoscale organization and function. With immunology, the explanation must go further, relating nanoscale biophysical phenomena to the manifestation of specific diseases, or the altered activity of specific immune cell types in a bodily compartment. What follows is a summary of how nanoscopy has elucidated single cell immunological function, and what might be achieved in the future to link quantifiable, nanoscale, biophysical phenomena with cell and whole tissue functionality. We explore where the gaps in our understanding occur, and how they might be addressed.

AB - Bridging the gap between traditional immunology and nanoscale biophysics has proved more difficult than originally thought. For cell biology applications however, super-resolution microscopy has already facilitated considerable advances. From neuronal segmentation to nuclear pores and 3D focal adhesion structure-nanoscopy has begun to illuminate links between nanoscale organization and function. With immunology, the explanation must go further, relating nanoscale biophysical phenomena to the manifestation of specific diseases, or the altered activity of specific immune cell types in a bodily compartment. What follows is a summary of how nanoscopy has elucidated single cell immunological function, and what might be achieved in the future to link quantifiable, nanoscale, biophysical phenomena with cell and whole tissue functionality. We explore where the gaps in our understanding occur, and how they might be addressed.

KW - Immunology

KW - Nanoscopy

KW - SMLM

KW - Super-resolution

KW - T cells

UR - http://www.scopus.com/inward/record.url?scp=85064388065&partnerID=8YFLogxK

U2 - 10.3389/fphy.2018.00157

DO - 10.3389/fphy.2018.00157

M3 - Review article

AN - SCOPUS:85064388065

VL - 6

JO - Frontiers in Physics

JF - Frontiers in Physics

IS - JAN

M1 - 157

ER -

Bridging the nanoscopy-immunology gap

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this