TY - JOUR
T1 - Bringing Chandelier Cells Out of the Shadows: Exploring the Development of a Unique Neuron Type in the Brain
AU - Lenherr, Clara
AU - Neves, Guilherme
AU - Guiomar de Oliveira, Marcio
AU - Burrone, Juan
PY - 2025/4/15
Y1 - 2025/4/15
N2 - Chandelier cells (ChCs) represent a unique GABAergic interneuron in the cortex, yet our knowledge of this sparsely populated cell type has remained equally sparse for many years. New tools, however, have brought ChCs out of the shadows, shedding light on their development and function in the rodent brain and, gradually, gaining insights into their properties in primates. This review will focus on the developmental mechanisms that define ChCs as a unique cell type and, where possible, draw parallels to studies in primates, particularly to work in human tissue. What emerges is a picture of a highly plastic neuron with a unique developmental trajectory that appears to be genetically and functionally conserved in the primate brain.
AB - Chandelier cells (ChCs) represent a unique GABAergic interneuron in the cortex, yet our knowledge of this sparsely populated cell type has remained equally sparse for many years. New tools, however, have brought ChCs out of the shadows, shedding light on their development and function in the rodent brain and, gradually, gaining insights into their properties in primates. This review will focus on the developmental mechanisms that define ChCs as a unique cell type and, where possible, draw parallels to studies in primates, particularly to work in human tissue. What emerges is a picture of a highly plastic neuron with a unique developmental trajectory that appears to be genetically and functionally conserved in the primate brain.
U2 - 10.1101/cshperspect.a041506
DO - 10.1101/cshperspect.a041506
M3 - Review article
SN - 1943-0264
JO - Cold Spring Harbor Perspectives In Biology
JF - Cold Spring Harbor Perspectives In Biology
ER -