Building a bridal chamber: development of the thalamus

Steffen Scholpp; Andrew Lumsden

doi:10.1016/j.tins.2010.05.003

Building a bridal chamber: development of the thalamus

Steffen Scholpp, Andrew Lumsden

King's College London

Karlsruhe Institute of Technology

Research output: Contribution to journal › Literature review › peer-review

95 Citations (Scopus)

Abstract

The thalamus is a central brain region that plays a crucial role in distributing incoming sensory information to appropriate regions of the cortex. The thalamus develops in the posterior part of the embryonic forebrain, where early cell fate decisions are controlled by a local signaling center - the mid-diencephalic organizer - which forms at the boundary between prospective prethalamus and thalamus. In this review we discuss recent observations of early thalamic development in zebrafish, chick, and mouse embryos, that reveal a conserved set of interactions between homeodomain transcription factors. These interactions position the organizer along the neuraxis. The most prominent of the organizer's signals, Sonic hedgehog, is necessary for conferring regional identity on the prethalamus and thalamus and for patterning their differentiation.

Original language	English
Pages (from-to)	373 - 380
Number of pages	8
Journal	Trends in Neurosciences
Volume	33
Issue number	8
DOIs	https://doi.org/10.1016/j.tins.2010.05.003
Publication status	Published - Aug 2010

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10.1016/j.tins.2010.05.003

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abstract = "The thalamus is a central brain region that plays a crucial role in distributing incoming sensory information to appropriate regions of the cortex. The thalamus develops in the posterior part of the embryonic forebrain, where early cell fate decisions are controlled by a local signaling center - the mid-diencephalic organizer - which forms at the boundary between prospective prethalamus and thalamus. In this review we discuss recent observations of early thalamic development in zebrafish, chick, and mouse embryos, that reveal a conserved set of interactions between homeodomain transcription factors. These interactions position the organizer along the neuraxis. The most prominent of the organizer's signals, Sonic hedgehog, is necessary for conferring regional identity on the prethalamus and thalamus and for patterning their differentiation.",

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AU - Lumsden, Andrew

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AB - The thalamus is a central brain region that plays a crucial role in distributing incoming sensory information to appropriate regions of the cortex. The thalamus develops in the posterior part of the embryonic forebrain, where early cell fate decisions are controlled by a local signaling center - the mid-diencephalic organizer - which forms at the boundary between prospective prethalamus and thalamus. In this review we discuss recent observations of early thalamic development in zebrafish, chick, and mouse embryos, that reveal a conserved set of interactions between homeodomain transcription factors. These interactions position the organizer along the neuraxis. The most prominent of the organizer's signals, Sonic hedgehog, is necessary for conferring regional identity on the prethalamus and thalamus and for patterning their differentiation.

U2 - 10.1016/j.tins.2010.05.003

DO - 10.1016/j.tins.2010.05.003

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VL - 33

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EP - 380

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 8

ER -

Building a bridal chamber: development of the thalamus

Abstract

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