Building and maintaining the axon initial segment

TY - JOUR

T1 - Building and maintaining the axon initial segment

AU - Grubb, Matthew S.

AU - Burrone, Juan

PY - 2010/8

Y1 - 2010/8

N2 - The axon initial segment is a unique neuronal subregion involved in the initiation of action potentials and in the control of axonal identity. Recent work has helped our understanding of how this specialised structure develops, not least in identifying possible mechanisms leading to the localisation of the AIS's master organiser protein, ankyrin-G. The most exciting current work, however, focuses on later aspects of AIS function and plasticity. Recent studies have shown that the AIS is subdivided into distinct structural and functional domains, have demonstrated how the AIS acts as a cytoplasmic barrier for axonal transport, and have discovered that the AIS can be surprisingly plastic in its responses to alterations in neuronal activity.

AB - The axon initial segment is a unique neuronal subregion involved in the initiation of action potentials and in the control of axonal identity. Recent work has helped our understanding of how this specialised structure develops, not least in identifying possible mechanisms leading to the localisation of the AIS's master organiser protein, ankyrin-G. The most exciting current work, however, focuses on later aspects of AIS function and plasticity. Recent studies have shown that the AIS is subdivided into distinct structural and functional domains, have demonstrated how the AIS acts as a cytoplasmic barrier for axonal transport, and have discovered that the AIS can be surprisingly plastic in its responses to alterations in neuronal activity.

U2 - 10.1016/j.conb.2010.04.012

DO - 10.1016/j.conb.2010.04.012

M3 - Article

SN - 1873-6882

VL - 20

SP - 481

EP - 488

JO - CURRENT OPINION IN NEUROBIOLOGY

JF - CURRENT OPINION IN NEUROBIOLOGY

IS - 4

ER -