Burden of Stroke in Europe: An Analysis of the Global Burden of Disease Study Findings From 2010 to 2019

Carlota F. Prendes*, Barbara Rantner, Tarek Hamwi, Jan Stana, Valery L. Feigin, Konstantinos Stavroulakis, Nikolaos Tsilimparis, GBD Collaborators Study Group, Carlota Fernandez Prendes, Barbara Rantner, Tarek Hamwi, Jan Stana, Prof Valery L Feigin, Konstantinos Stavroulakis, Nikolaos Tsilimparis, Prof Victor Aboyans, Rufus Olusola Akinyemi, Prof Rustam Al-Shahi Salman, Anton A Artamonov, Avinash AujayebMarzia Baldereschi, Sanjay Basu, Prof Yannick Béjot, Luis Belo, Derrick A Bennett, Akshaya Srikanth Bhagavathula, Boris Bikbov, Prof Hermann Brenner, Florentino Luciano Caetano dos Santos, Prof Juan J Carrero, Prof Felix Carvalho, Prof Alberico L Catapano, Periklis Charalampous, Prof Hanne Christensen, Sheng-Chia Chung, Paolo Angelo Cortesi, Vera Marisa Costa, Malgorzata Cyganska, Emanuele D’Amico, Kairat Davletov, Klara Georgieva Dokova, Abdel Douiri, Adeniyi Francis Fagbamigbe, Florian Fischer, Nermin Ghith, Simona Giampaoli, Prof Paramjit Singh Gill, Elena V Gnedovskaya, Mariam Molokhia, Hatem A Wafa, Yanzhong Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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While most European Regions perform well in global comparisons, large discrepancies within stroke epidemiological parameters exist across Europe. The objective of this analysis was to evaluate the stroke burden across European regions and countries in 2019 and its difference to 2010.

The GBD 2019 analytical tools were used to evaluate regional and country-specific estimates of incidence, prevalence, deaths, and disability-adjusted life years of stroke for the European Region as defined by the World Health Organization, with its 53 member countries (EU-53) and for European Union as defined in 2019, with its 28 member countries (EU-28), between 2010 and 2019. Results were analyzed at a regional, subregional, and country level.

In EU-53, the absolute number of incident and prevalent strokes increased by 2% (uncertainty interval [UI], 0%–4%), from 1 767 280 to 1 802 559 new cases, and by 4% (UI, 3%–5%) between 2010 and 2019, respectively. In EU-28, the absolute number of prevalent strokes and stroke-related deaths increased by 4% (UI, 2%–5%) and by 6% (UI, 1%–10%), respectively. All-stroke age-standardized mortality rates, however, decreased by 18% (UI, −22% to −14%), from 82 to 67 per 100 000 people in the EU-53, and by 15% (UI, −18% to −11%), from 49.3 to 42.0 per 100 000 people in EU-28. Despite most countries presenting reductions in age-adjusted incidence, prevalence, mortality, and disability-adjusted life year rates, these rates remained 1.4×, 1.2×, 1.6×, and 1.7× higher in EU-53 in comparison to the EU-28.

EU-53 showed a 2% increase in incident strokes, while they remained stable in EU-28. Age-standardized rates were consistently lower for all-stroke burden parameters in EU-28 in comparison to EU-53, and huge discrepancies in incidence, prevalence, mortality, and disability-adjusted life-year rates were observed between individual countries.
Original languageEnglish
Pages (from-to)432-442
Number of pages11
Issue number2
Early online date22 Jan 2024
Publication statusPublished - 1 Feb 2024


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