Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients

TY - JOUR

T1 - Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients

AU - Tasker, A

AU - Ballard, C G

AU - Joachim, C

AU - Warden, D R

AU - Okello, E J

AU - Perry, R H

AU - Khan, N

AU - Smith, A D

AU - Lehmann, D J

AU - Perry, E K

PY - 2008/9/19

Y1 - 2008/9/19

N2 - There is evidence to suggest an involvement of the K variant of the butyrylcholinesterase gene (BCHE) in dementia. We have examined the relationship between BCHE genotype and butyrylcholinesterase (BuChE) activity in autopsy brain tissue. We studied 164 autopsy cases, 144 with dementia and 20 controls, including 13 K homozygotes and 48 K heterozygotes, from three centres: Newcastle, Oxford and London. Mean BuChE activity in temporal cortex was 37% higher in K homozygotes than in wild-type homozygotes. Linear regression analysis, controlling for gender, diagnosis, age at death and study centre, showed that the number of BCHE-K alleles was associated with increasing BuChE activity (p = 0.009). (C) 2008 Elsevier Ireland Ltd. All rights reserved

AB - There is evidence to suggest an involvement of the K variant of the butyrylcholinesterase gene (BCHE) in dementia. We have examined the relationship between BCHE genotype and butyrylcholinesterase (BuChE) activity in autopsy brain tissue. We studied 164 autopsy cases, 144 with dementia and 20 controls, including 13 K homozygotes and 48 K heterozygotes, from three centres: Newcastle, Oxford and London. Mean BuChE activity in temporal cortex was 37% higher in K homozygotes than in wild-type homozygotes. Linear regression analysis, controlling for gender, diagnosis, age at death and study centre, showed that the number of BCHE-K alleles was associated with increasing BuChE activity (p = 0.009). (C) 2008 Elsevier Ireland Ltd. All rights reserved

U2 - 10.1016/j.neulet.2008.07.023

DO - 10.1016/j.neulet.2008.07.023

M3 - Article

VL - 442

SP - 297

EP - 299

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -