Cadherins regulate nuclear topography and function of developing ocular motor circuitry

Athene Knüfer, Giovanni Diana, Gregory S. Walsh, Jonathan Dw Clarke, Sarah Guthrie

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


In the vertebrate central nervous system, groups of functionally related neurons, including cranial motor neurons of the brainstem, are frequently organised as nuclei. The molecular mechanisms governing the emergence of nuclear topography and circuit function are poorly understood. Here we investigate the role of cadherin-mediated adhesion in the development of zebrafish ocular motor (sub)nuclei. We find that developing ocular motor (sub)nuclei differentially express classical cadherins. Perturbing cadherin function in these neurons results in distinct defects in neuronal positioning, including scattering of dorsal cells and defective contralateral migration of ventral subnuclei. In addition, we show that cadherin-mediated interactions between adjacent subnuclei are critical for subnucleus position. We also find that disrupting cadherin adhesivity in dorsal oculomotor neurons impairs the larval optokinetic reflex, suggesting that neuronal clustering is important for co-ordinating circuit function. Our findings reveal that cadherins regulate distinct aspects of cranial motor neuron positioning and establish subnuclear topography and motor function.

Original languageEnglish
Article numbere56725
Pages (from-to)1-25
Number of pages25
Publication statusPublished - 1 Oct 2020


  • brainstem
  • cadherins
  • cell adhesion
  • developmental biology
  • motor neuron
  • neuroscience
  • ocular motor system
  • oculomotor
  • zebrafish


Dive into the research topics of 'Cadherins regulate nuclear topography and function of developing ocular motor circuitry'. Together they form a unique fingerprint.

Cite this