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Calcium silicate‐based root canal sealers: A narrative review and clinical perspectives

Research output: Contribution to journalReview articlepeer-review

Germain Sfeir, Carla Zogheib, Shanon Patel, Thomas Giraud, Venkateshbabu Nagendrababu, Frédéric Bukiet

Original languageEnglish
Article number3965
Issue number14
Published2 Jul 2021

Bibliographical note

Funding Information: This research was funded by the University of Saint?Joseph, Beirut, Lebanon. Funding Information: Funding: This research was funded by the University of Saint‐Joseph, Beirut, Lebanon. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors


Over the last two decades, calcium silicate‐based materials have grown in popularity. As root canal sealers, these formulations have been extensively investigated and compared with conventional sealers, such as zinc oxide–eugenol and epoxy resin‐based sealers, in in vitro studies that showed their promising properties, especially their biocompatibility, antimicrobial properties, and certain bioactivity. However, the consequence of their higher solubility is a matter of debate and still needs to be clarified, because it may affect their long‐term sealing ability. Unlike conventional sealers, those sealers are hydraulic, and their setting is conditioned by the presence of humidity. Current evidence reveals that the properties of calcium silicate‐based sealers vary depending on their formulation. To date, only a few short‐term investigations addressed the clinical outcome of calcium silicate‐based root canal sealers. Their use has been showed to be mainly based on practitioners’ clinical habits rather than manufacturers’ recommendations or available evidence. However, their particular behavior implies modifications of the clinical protocol used for conventional sealers. This narrative review aimed to discuss the properties of calcium silicate‐based sealers and their clinical implications, and to propose rational indications for these sealers based on the current knowledge.

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