King's College London

Research portal

Calcium/calmodulin-dependent kinase II and memory destabilization: a new role in memory maintenance

Research output: Contribution to journalReview article

Fabio Antonio Vigil, Karl Peter Giese

Original languageEnglish
Pages (from-to)12-23
JournalJournal of Neurochemistry
Volume147
Issue number1
Early online date28 Apr 2018
DOIs
Accepted/In press17 Apr 2018
E-pub ahead of print28 Apr 2018

Documents

King's Authors

Abstract

In this review, we discuss the poorly explored role of calcium/calmodulin-dependent protein kinase II (CaMKII) in memory maintenance, and its influence on memory destabilization. After a brief review on CaMKII and memory destabilization, we present critical pieces of evidence suggesting that CaMKII activity increases retrieval-induced memory destabilization. We then proceed to propose two potential molecular pathways to explain the association between CaMKII activation and increased memory destabilization. This review will pinpoint gaps in our knowledge and discuss some “controversial” observations, establishing the basis for new experiments on the role of CaMKII in memory reconsolidation. The role of CaMKII in memory destabilization is of great clinical relevance. Still, due to the lack of scientific literature on the subject, more basic science research is necessary to pursue this pathway as a clinical tool.

Download statistics

No data available

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454