CaMKII autophosphorylation-dependent learning and memory

Fabio A.B. Vigil; Karl Peter Giese

doi:10.1007/978-3-319-24364-1_4

CaMKII autophosphorylation-dependent learning and memory

Fabio A.B. Vigil, Karl Peter Giese^*

^*Corresponding author for this work

Basic and Clinical Neuroscience

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Calcium/calmodulin-dependent kinase II is the most abundant protein in the post-synaptic density. It has been proposed to play an important role on learning and memory due to its autophosphorylation ability. Once phosphorylated in the right position CaMKII remains active even after the initial stimulus has fi nished. Although the model seems quite logical and straight forward the function of CaMKII autophosphorylation in learning and memory is still a matter of discussion. While its importance in learning is well established there isn’t still enough data to reach a conclusion on memory. In this chapter we will discuss CaMKII autophosphorylation theory, its importance for LTP, learning, memory and possible relevance in different diseases.

Original language	English
Title of host publication	Novel Mechanisms of Memory
Publisher	Springer International Publishing Switzerland
Pages	67-87
Number of pages	21
ISBN (Electronic)	9783319243641
ISBN (Print)	9783319243627
DOIs	https://doi.org/10.1007/978-3-319-24364-1_4
Publication status	Published - 1 Jan 2015

Keywords

Hippocampus
LTP
Memory
Signalling
Synaptic plasticity

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10.1007/978-3-319-24364-1_4

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N2 - Calcium/calmodulin-dependent kinase II is the most abundant protein in the post-synaptic density. It has been proposed to play an important role on learning and memory due to its autophosphorylation ability. Once phosphorylated in the right position CaMKII remains active even after the initial stimulus has fi nished. Although the model seems quite logical and straight forward the function of CaMKII autophosphorylation in learning and memory is still a matter of discussion. While its importance in learning is well established there isn’t still enough data to reach a conclusion on memory. In this chapter we will discuss CaMKII autophosphorylation theory, its importance for LTP, learning, memory and possible relevance in different diseases.

AB - Calcium/calmodulin-dependent kinase II is the most abundant protein in the post-synaptic density. It has been proposed to play an important role on learning and memory due to its autophosphorylation ability. Once phosphorylated in the right position CaMKII remains active even after the initial stimulus has fi nished. Although the model seems quite logical and straight forward the function of CaMKII autophosphorylation in learning and memory is still a matter of discussion. While its importance in learning is well established there isn’t still enough data to reach a conclusion on memory. In this chapter we will discuss CaMKII autophosphorylation theory, its importance for LTP, learning, memory and possible relevance in different diseases.

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KW - Signalling

KW - Synaptic plasticity

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CaMKII autophosphorylation-dependent learning and memory

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Keywords

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