Can sodium-glucose cotransporter 2 inhibitors ‘spin the thread of life’?

Giuseppe Maltese, Theocharis Koufakis, Kalliopi Kotsa, Janaka Karalliedde

Research output: Contribution to journalShort surveypeer-review

1 Citation (Scopus)


Sodium-glucose cotransporter 2 inhibitors (SGLT2i) were first used as antidiabetic agents that lower the blood glucose levels by promoting glycosuria. In recent years, randomised clinical trials have demonstrated that SGLT2i reduce cardiovascular-renal events and all-cause mortality in people with and without diabetes. The cardio-renal benefits observed are independent of glucose lowering effect and multiple mechanisms have been proposed for these results. SGLT2i can exert anti-ageing effects on the vasculature and other body organs through several signalling pathways including the activation of the nuclear factor erythroid-2-related factor 2 and the induction of antioxidant enzymes. We speculate that the pro-longevity effects of the SGLT2i are mediated by soluble Klotho, an anti-ageing kidney-derived hormone and an emerging therapeutic target for cardio-renal diseases.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
Issue number1
Early online date7 Nov 2022
Publication statusPublished - Jan 2023


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