CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES

Manasi Nandi; Miquel Serna Pascual; Maria Volovaya; Yujia Wu; Rebecca F. D'Cruz; Philip Aston; Carolyn Lam; Aileen  Milne; Mary McElroy

doi:10.1089/jamp.2023.ab01.abstrac

CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES

Manasi Nandi, Miquel Serna Pascual, Maria Volovaya, Yujia Wu, Rebecca F. D'Cruz, Philip Aston, Carolyn Lam, Aileen Milne, Mary McElroy

Institute of Pharmaceutical Science

Research output: Chapter in Book/Report/Conference proceeding › Conference paper

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Abstract

Summary: Symmetric Projection Attractor Reconstruction (SPAR) is a newly developed mathematical technique. It quantifies the shape and variability changes of cyclic waveforms by using all the available digital data, most of which is typically discarded during conventional analysis. We demonstrate the additive value of this technique in more sensitively quantifying lung function changes in a preclinical lung fibrosis model and in patients with COPD.

Original language	English
Title of host publication	CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES
Publisher	Mary Ann Liebert, Inc., publishers
DOIs	https://doi.org/10.1089/jamp.2023.ab01.abstrac
Publication status	Published - Jun 2023

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10.1089/jamp.2023.ab01.abstrac

CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES

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Nandi, M., Serna Pascual, M., Volovaya, M., Wu, Y., D'Cruz, R. F., Aston, P., Lam, C., Milne, A., & McElroy, M. (2023). CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES. In CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES Mary Ann Liebert, Inc., publishers. https://doi.org/10.1089/jamp.2023.ab01.abstrac

Nandi, Manasi ; Serna Pascual, Miquel ; Volovaya, Maria et al. / CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES. CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES. Mary Ann Liebert, Inc., publishers, 2023.

@inbook{91e02b9419df4229a0c815118ee0cad3,

title = "CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES",

abstract = "Summary: Symmetric Projection Attractor Reconstruction (SPAR) is a newly developed mathematical technique. It quantifies the shape and variability changes of cyclic waveforms by using all the available digital data, most of which is typically discarded during conventional analysis. We demonstrate the additive value of this technique in more sensitively quantifying lung function changes in a preclinical lung fibrosis model and in patients with COPD.",

author = "Manasi Nandi and {Serna Pascual}, Miquel and Maria Volovaya and Yujia Wu and D'Cruz, {Rebecca F.} and Philip Aston and Carolyn Lam and Aileen Milne and Mary McElroy",

year = "2023",

month = jun,

doi = "10.1089/jamp.2023.ab01.abstrac",

language = "English",

booktitle = "CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES",

publisher = "Mary Ann Liebert, Inc., publishers",

}

Nandi, M , Serna Pascual, M, Volovaya, M, Wu, Y, D'Cruz, RF, Aston, P, Lam, C, Milne, A & McElroy, M 2023, CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES. in CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES. Mary Ann Liebert, Inc., publishers. https://doi.org/10.1089/jamp.2023.ab01.abstrac

CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES. / Nandi, Manasi ; Serna Pascual, Miquel; Volovaya, Maria et al.
CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES. Mary Ann Liebert, Inc., publishers, 2023.

Research output: Chapter in Book/Report/Conference proceeding › Conference paper

TY - CHAP

T1 - CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES

AU - Nandi, Manasi

AU - Serna Pascual, Miquel

AU - Volovaya, Maria

AU - Wu, Yujia

AU - D'Cruz, Rebecca F.

AU - Aston, Philip

AU - Lam, Carolyn

AU - Milne, Aileen

AU - McElroy, Mary

PY - 2023/6

Y1 - 2023/6

N2 - Summary: Symmetric Projection Attractor Reconstruction (SPAR) is a newly developed mathematical technique. It quantifies the shape and variability changes of cyclic waveforms by using all the available digital data, most of which is typically discarded during conventional analysis. We demonstrate the additive value of this technique in more sensitively quantifying lung function changes in a preclinical lung fibrosis model and in patients with COPD.

AB - Summary: Symmetric Projection Attractor Reconstruction (SPAR) is a newly developed mathematical technique. It quantifies the shape and variability changes of cyclic waveforms by using all the available digital data, most of which is typically discarded during conventional analysis. We demonstrate the additive value of this technique in more sensitively quantifying lung function changes in a preclinical lung fibrosis model and in patients with COPD.

U2 - 10.1089/jamp.2023.ab01.abstrac

DO - 10.1089/jamp.2023.ab01.abstrac

M3 - Conference paper

BT - CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES

PB - Mary Ann Liebert, Inc., publishers

ER -

Nandi M , Serna Pascual M, Volovaya M, Wu Y, D'Cruz RF, Aston P et al. CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES. In CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES. Mary Ann Liebert, Inc., publishers. 2023 doi: 10.1089/jamp.2023.ab01.abstrac

CAN WE MAKE BETTER USE OF ROUTINE PHYSIOLOGICAL SIGNALS? USING MATHS TO IMPROVE THE SENSITIVITY OF DETECTING DRUG OR DISEASE‐INDUCED CHANGES

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