Cancer risks in women with 2 breast or ovarian cancers: Clues to genetic cancer susceptibility

TY - JOUR

T1 - Cancer risks in women with 2 breast or ovarian cancers: Clues to genetic cancer susceptibility

AU - Evans, H S

AU - Lewis, C M

AU - Robinson, D

AU - Bell, C M J

AU - Moller, H

AU - Hodgson, S V

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Women diagnosed with 2 cancers of the breast and/or ovary are at higher risk of developing subsequent cancers. Using registrations from the Thames Cancer Registry, we quantified the risks at different cancer sites. Increased risks were found for cancers that are part of the BRCA1 and BRCA2 tumour spectrum: oropharyngeal cancer, malignant melanoma of the skin (BRCA2) and colon cancer (BRCA1). We also found significantly increased risks of myeloid leukaemia (probably due to radiotherapy) and of cancer of the corpus uteri (which may be due to hormonal factors). (C) 2001 Wiley-Liss. Inc.

AB - Women diagnosed with 2 cancers of the breast and/or ovary are at higher risk of developing subsequent cancers. Using registrations from the Thames Cancer Registry, we quantified the risks at different cancer sites. Increased risks were found for cancers that are part of the BRCA1 and BRCA2 tumour spectrum: oropharyngeal cancer, malignant melanoma of the skin (BRCA2) and colon cancer (BRCA1). We also found significantly increased risks of myeloid leukaemia (probably due to radiotherapy) and of cancer of the corpus uteri (which may be due to hormonal factors). (C) 2001 Wiley-Liss. Inc.

UR - http://www.scopus.com/inward/record.url?scp=0035545828&partnerID=8YFLogxK

U2 - 10.1002/ijc.1534

DO - 10.1002/ijc.1534

M3 - Article

SN - 1097-0215

VL - 94

SP - 758

EP - 759

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 5

ER -