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Cancer-associated thrombosis: Regulatory mechanisms and emerging directions

Research output: Contribution to journalArticle

Alice Prodger, Prakash Saha, Alberto Smith, Colin E. Evans

Original languageEnglish
JournalAdvances in Experimental Medicine And Biology
Volume906
DOIs
Publication statusPublished - 1 Jan 2017

King's Authors

Abstract

Venous thrombosis is a common complication in cancer patients, and some cancer chemotherapies are associated with an increased risk of venous thromboembolism. The regulatory mechanisms that control thrombus formation and subsequent resolution in patients with cancer, however, are incompletely understood, and novel treatments for cancerassociated thrombosis may arise from a better understanding of such mechanisms. In this chapter, pathways that regulate cancer-associated thrombus formation are outlined, and the effects of anti-angiogenic cancer chemotherapies on venous thrombus resolution are highlighted. Potentially pro-thrombotic effects of anti-angiogenic agents are important considerations when managing the complications of venous thrombosis in cancer patients.

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