Candida albicans and candidalysin in inflammatory disorders and cancer

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)

Abstract

As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C. albicans has also been quietly linked with a variety of inflammatory disorders, to which it has traditionally been considered incidental; recent studies may now provide new aspects of these relationships for further consideration. This review provides a novel perspective on the impact of C. albicans and its peptide toxin, candidalysin, on human health, exploring their contributions to pathology within a variety of diseases.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalImmunology
Volume162
Issue number1
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Candida albicans
  • candidalysin
  • gut barrier
  • IL-17
  • mucosal disease

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