Candida albicans-epithelial interactions and pathogenicity mechanisms: Scratching the surface

David Moyes*, Jonathan Richardson, Julian Naglik

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

125 Citations (Scopus)
216 Downloads (Pure)

Abstract

Until recently, epithelial cells have been a largely ignored component of host responses to microbes. However, this has been largely overturned over the last decade as an ever increasing number of studies have highlighted the key role that these cells play in many of our interactions with our microbiota and pathogens. Interactions of these cells with Candida albicans have been shown to be critical not just in host responses, but also in fungal cell responses, regulating fungal morphology and gene expression profile. In this review, we will explore the interactions between C. albicans and epithelial cells, and discuss how these interactions affect our relationship with this fungus.

Original languageEnglish
Pages (from-to)338-346
Number of pages9
JournalVirulence
Volume6
Issue number4
Early online date25 Feb 2015
DOIs
Publication statusPublished - 1 Jun 2015

Keywords

  • Adhesion
  • Candida albicans
  • Epithelial cells
  • Fungal infection
  • Fungal recognition
  • Host-pathogen interaction
  • Invasion

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