Candida albicans interactions with mucosal surfaces during health and disease

Spyridoula Angeliki Nikou; Nessim Kichik; Rhys Brown; Nicole O. Ponde; Jemima Ho; Julian R. Naglik; Jonathan P. Richardson

Candida albicans interactions with mucosal surfaces during health and disease

Spyridoula Angeliki Nikou, Nessim Kichik, Rhys Brown, Nicole O. Ponde, Jemima Ho, Julian R. Naglik, Jonathan P. Richardson

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Abstract

Flexible adaptation to the host environment is a critical trait that underpins the success of numerous microbes. The polymorphic fungus Candida albicans has evolved to persist in the numerous challenging niches of the human body. The interaction of C. albicans with a mucosal surface is an essential pre-requisite for fungal colonisation and epitomises the complex interface between microbe and host. C. albicans exhibits numerous adaptations to a healthy host that permit commensal colonisation of mucosal surfaces without provoking an overt immune response that may lead to clearance. Conversely, fungal adaptation to impaired immune fitness at mucosal surfaces enables pathogenic infiltration into underlying tissues, often with devastating consequences. This review will summarise our current understanding of the complex interactions that occur between C. albicans and the mucosal surfaces of the human body.

Original language	English
Journal	Pathogens
Publication status	Accepted/In press - 15 Apr 2019

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Candida albicans interaction_NIKOU_Accepted15April2019_GREEN AAMAccepted author manuscript, 572 KBLicence: CC BY

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title = "Candida albicans interactions with mucosal surfaces during health and disease",

abstract = "Flexible adaptation to the host environment is a critical trait that underpins the success of numerous microbes. The polymorphic fungus Candida albicans has evolved to persist in the numerous challenging niches of the human body. The interaction of C. albicans with a mucosal surface is an essential pre-requisite for fungal colonisation and epitomises the complex interface between microbe and host. C. albicans exhibits numerous adaptations to a healthy host that permit commensal colonisation of mucosal surfaces without provoking an overt immune response that may lead to clearance. Conversely, fungal adaptation to impaired immune fitness at mucosal surfaces enables pathogenic infiltration into underlying tissues, often with devastating consequences. This review will summarise our current understanding of the complex interactions that occur between C. albicans and the mucosal surfaces of the human body.",

author = "Nikou, {Spyridoula Angeliki} and Nessim Kichik and Rhys Brown and Ponde, {Nicole O.} and Jemima Ho and Naglik, {Julian R.} and Richardson, {Jonathan P.}",

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language = "English",

journal = "Pathogens",

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T1 - Candida albicans interactions with mucosal surfaces during health and disease

AU - Nikou, Spyridoula Angeliki

AU - Kichik, Nessim

AU - Brown, Rhys

AU - Ponde, Nicole O.

AU - Ho, Jemima

AU - Naglik, Julian R.

AU - Richardson, Jonathan P.

PY - 2019/4/15

Y1 - 2019/4/15

N2 - Flexible adaptation to the host environment is a critical trait that underpins the success of numerous microbes. The polymorphic fungus Candida albicans has evolved to persist in the numerous challenging niches of the human body. The interaction of C. albicans with a mucosal surface is an essential pre-requisite for fungal colonisation and epitomises the complex interface between microbe and host. C. albicans exhibits numerous adaptations to a healthy host that permit commensal colonisation of mucosal surfaces without provoking an overt immune response that may lead to clearance. Conversely, fungal adaptation to impaired immune fitness at mucosal surfaces enables pathogenic infiltration into underlying tissues, often with devastating consequences. This review will summarise our current understanding of the complex interactions that occur between C. albicans and the mucosal surfaces of the human body.

AB - Flexible adaptation to the host environment is a critical trait that underpins the success of numerous microbes. The polymorphic fungus Candida albicans has evolved to persist in the numerous challenging niches of the human body. The interaction of C. albicans with a mucosal surface is an essential pre-requisite for fungal colonisation and epitomises the complex interface between microbe and host. C. albicans exhibits numerous adaptations to a healthy host that permit commensal colonisation of mucosal surfaces without provoking an overt immune response that may lead to clearance. Conversely, fungal adaptation to impaired immune fitness at mucosal surfaces enables pathogenic infiltration into underlying tissues, often with devastating consequences. This review will summarise our current understanding of the complex interactions that occur between C. albicans and the mucosal surfaces of the human body.

M3 - Article

SN - 2076-0817

JO - Pathogens

JF - Pathogens

ER -

Candida albicans interactions with mucosal surfaces during health and disease

Abstract

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