Candida albicans proteinases and host/pathogen interactions

J Naglik, A Albrecht, O Bader, B Hube

Research output: Contribution to journalLiterature reviewpeer-review

275 Citations (Scopus)

Abstract

Candida infections are common, debilitating and often recurring fungal diseases and a problem of significant clinical importance. Candida albicans, the most virulent of the Candida spp., can cause severe mucosal and life-threatening systemic infections in immunocompromised hosts. Attributes that contribute to C. albicans virulence include adhesion, hyphal formation, phenotypic switching and extracellular hydrolytic enzyme production. The extracellular hydrolytic enzymes, especially the secreted aspartyl proteinases (Saps), are one of few gene products that have been shown to directly contribute to C. albicans pathogenicity. Because C. albicans is able to colonize and infect almost every tissue in the human host, it may be crucial for the fungus to possess a number of similar but independently regulated and functionally distinct secreted proteinases to provide sufficient flexibility in order to survive and promote infection at different niche sites. The aim of this review is to explore the functional roles of the C. albicans proteinases and how they may contribute to the host/pathogen interaction in vivo.
Original languageEnglish
Pages (from-to)915 - 926
Number of pages12
JournalCellular Microbiology
Volume6
Issue number10
DOIs
Publication statusPublished - Oct 2004

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