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Candida albicans-epithelial interactions and pathogenicity mechanisms: Scratching the surface

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)338-346
Number of pages9
JournalVirulence
Volume6
Issue number4
Early online date25 Feb 2015
DOIs
Accepted/In press16 Jan 2015
E-pub ahead of print25 Feb 2015
Published1 Jun 2015

Documents

  • 20_January_2016_Candida_al

    20_January_2016_Candida_al.pdf, 1.05 MB, application/pdf

    Uploaded date:20 Jan 2016

    Version:Final published version

    Licence:CC BY

King's Authors

Abstract

Until recently, epithelial cells have been a largely ignored component of host responses to microbes. However, this has been largely overturned over the last decade as an ever increasing number of studies have highlighted the key role that these cells play in many of our interactions with our microbiota and pathogens. Interactions of these cells with Candida albicans have been shown to be critical not just in host responses, but also in fungal cell responses, regulating fungal morphology and gene expression profile. In this review, we will explore the interactions between C. albicans and epithelial cells, and discuss how these interactions affect our relationship with this fungus.

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