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Candidalysin is a potent trigger of alarmin and antimicrobial peptide release in epithelial cells

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Candidalysin is a potent trigger of alarmin and antimicrobial peptide release in epithelial cells. / Ho, Jemima; Wickramasinghe, Don N.; Nikou, Spyridoula-Angeliki et al.

In: Cells, Vol. 9, No. 3, 699, 03.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Ho, J, Wickramasinghe, DN, Nikou, S-A, Hube, B, Richardson, JP & Naglik, JR 2020, 'Candidalysin is a potent trigger of alarmin and antimicrobial peptide release in epithelial cells', Cells, vol. 9, no. 3, 699. https://doi.org/10.3390/cells9030699

APA

Ho, J., Wickramasinghe, D. N., Nikou, S-A., Hube, B., Richardson, J. P., & Naglik, J. R. (2020). Candidalysin is a potent trigger of alarmin and antimicrobial peptide release in epithelial cells. Cells, 9(3), [699]. https://doi.org/10.3390/cells9030699

Vancouver

Ho J, Wickramasinghe DN, Nikou S-A, Hube B, Richardson JP, Naglik JR. Candidalysin is a potent trigger of alarmin and antimicrobial peptide release in epithelial cells. Cells. 2020 Mar;9(3). 699. https://doi.org/10.3390/cells9030699

Author

Ho, Jemima ; Wickramasinghe, Don N. ; Nikou, Spyridoula-Angeliki et al. / Candidalysin is a potent trigger of alarmin and antimicrobial peptide release in epithelial cells. In: Cells. 2020 ; Vol. 9, No. 3.

Bibtex Download

@article{75355dfc74a9430a9ebe08833be799af,
title = "Candidalysin is a potent trigger of alarmin and antimicrobial peptide release in epithelial cells",
abstract = "Host released alarmins and antimicrobial peptides (AMPs) are highly effective as antifungal agents and inducers. Whilst some are expressed constitutively at mucosal tissues, the primary site of many infections, others are elicited in response to pathogens. In the context of Candida albicans, the fungal factors inducing release of these innate immune molecules are poorly defined. Herein, we identify candidalysin as a potent trigger of several key alarmins and AMPs known to possess potent anti-Candida functions. We also find extracellular ATP to be an important activator of candidalysin-induced epithelial signalling responses, namely EGFR and MAPK signaling, which mediate downstream innate immunity during oral epithelial infection. The data provide novel mechanistic insight into the induction of multiple key alarmins and AMPs from epithelial cells, important for antifungal defences against C. albicans.",
keywords = "Candida, candidalysin, antiomicrobial peptide, alarmin, ATP, defensin",
author = "Jemima Ho and Wickramasinghe, {Don N.} and Spyridoula-Angeliki Nikou and Bernhard Hube and Richardson, {Jonathan P.} and Naglik, {Julian R.}",
year = "2020",
month = mar,
doi = "10.3390/cells9030699",
language = "English",
volume = "9",
journal = "Cells",
issn = "2073-4409",
publisher = "MDPI",
number = "3",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Candidalysin is a potent trigger of alarmin and antimicrobial peptide release in epithelial cells

AU - Ho, Jemima

AU - Wickramasinghe, Don N.

AU - Nikou, Spyridoula-Angeliki

AU - Hube, Bernhard

AU - Richardson, Jonathan P.

AU - Naglik, Julian R.

PY - 2020/3

Y1 - 2020/3

N2 - Host released alarmins and antimicrobial peptides (AMPs) are highly effective as antifungal agents and inducers. Whilst some are expressed constitutively at mucosal tissues, the primary site of many infections, others are elicited in response to pathogens. In the context of Candida albicans, the fungal factors inducing release of these innate immune molecules are poorly defined. Herein, we identify candidalysin as a potent trigger of several key alarmins and AMPs known to possess potent anti-Candida functions. We also find extracellular ATP to be an important activator of candidalysin-induced epithelial signalling responses, namely EGFR and MAPK signaling, which mediate downstream innate immunity during oral epithelial infection. The data provide novel mechanistic insight into the induction of multiple key alarmins and AMPs from epithelial cells, important for antifungal defences against C. albicans.

AB - Host released alarmins and antimicrobial peptides (AMPs) are highly effective as antifungal agents and inducers. Whilst some are expressed constitutively at mucosal tissues, the primary site of many infections, others are elicited in response to pathogens. In the context of Candida albicans, the fungal factors inducing release of these innate immune molecules are poorly defined. Herein, we identify candidalysin as a potent trigger of several key alarmins and AMPs known to possess potent anti-Candida functions. We also find extracellular ATP to be an important activator of candidalysin-induced epithelial signalling responses, namely EGFR and MAPK signaling, which mediate downstream innate immunity during oral epithelial infection. The data provide novel mechanistic insight into the induction of multiple key alarmins and AMPs from epithelial cells, important for antifungal defences against C. albicans.

KW - Candida

KW - candidalysin

KW - antiomicrobial peptide

KW - alarmin

KW - ATP

KW - defensin

U2 - 10.3390/cells9030699

DO - 10.3390/cells9030699

M3 - Article

VL - 9

JO - Cells

JF - Cells

SN - 2073-4409

IS - 3

M1 - 699

ER -

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