Candidate blood proteome markers of Alzheimer's disease onset and progression: A systematic review and replication study

Chantal Bazenet; Steven Kiddle; Martina Sattlecker; Petroula Proitsi; Andrew Simmons; Eric Westman; Sally Nelson; David Sterling; Steven Williams; Angela Hodges; Caroline Johnston; Richard Dobson; Hilkka Soininen; Iwona Kloszewska; Patrizia Mecocci; Magda Tsolaki; Bruno Vellas; Stephen Newhouse; Richard James Butler Dobson; Simon H Lovestone

doi:10.1016/j.jalz.2013.08.178

Candidate blood proteome markers of Alzheimer's disease onset and progression: A systematic review and replication study

Chantal Bazenet, Steven Kiddle, Martina Sattlecker, Petroula Proitsi, Andrew Simmons, Eric Westman, Sally Nelson, David Sterling, Steven Williams, Angela Hodges, Caroline Johnston, Richard Dobson, Hilkka Soininen, Iwona Kloszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Stephen Newhouse, Richard James Butler Dobson, Simon H Lovestone

King's College London

Research output: Contribution to journal › Poster abstract › peer-review

Abstract

A blood-based protein biomarker, or set of protein biomarkers, that could predict onset and progression of AD would have great utility; potentially clinically, but also for clinical trials and especially in the selection of subjects for preventative trials. Numerous discovery studies for blood-based protein markers of AD have been undertaken during the last decade, ranging from proteomics technologies using both gel and non-gel based mass spectrometry (MS) to antibody capture. The failure to replicate discoveries has been a fundamental issue regarding the development of a useful diagnostic panel to date.

Original language	Undefined/Unknown
Article number	P4-344
Pages (from-to)	P857-P858
Journal	Alzheimer's Dementia: The Journal of the Alzheimer's Association
Volume	9
Issue number	4
DOIs	https://doi.org/10.1016/j.jalz.2013.08.178
Publication status	Published - 2013

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10.1016/j.jalz.2013.08.178

Cite this

Bazenet, C., Kiddle, S., Sattlecker, M., Proitsi, P., Simmons, A., Westman, E., Nelson, S., Sterling, D., Williams, S., Hodges, A., Johnston, C., Dobson, R., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Newhouse, S., Dobson, R. J. B., & Lovestone, S. H. (2013). Candidate blood proteome markers of Alzheimer's disease onset and progression: A systematic review and replication study. Alzheimer's Dementia: The Journal of the Alzheimer's Association, 9(4), P857-P858. Article P4-344. https://doi.org/10.1016/j.jalz.2013.08.178

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title = "Candidate blood proteome markers of Alzheimer's disease onset and progression: A systematic review and replication study",

abstract = "A blood-based protein biomarker, or set of protein biomarkers, that could predict onset and progression of AD would have great utility; potentially clinically, but also for clinical trials and especially in the selection of subjects for preventative trials. Numerous discovery studies for blood-based protein markers of AD have been undertaken during the last decade, ranging from proteomics technologies using both gel and non-gel based mass spectrometry (MS) to antibody capture. The failure to replicate discoveries has been a fundamental issue regarding the development of a useful diagnostic panel to date.",

author = "Chantal Bazenet and Steven Kiddle and Martina Sattlecker and Petroula Proitsi and Andrew Simmons and Eric Westman and Sally Nelson and David Sterling and Steven Williams and Angela Hodges and Caroline Johnston and Richard Dobson and Hilkka Soininen and Iwona Kloszewska and Patrizia Mecocci and Magda Tsolaki and Bruno Vellas and Stephen Newhouse and Dobson, {Richard James Butler} and Lovestone, {Simon H}",

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doi = "10.1016/j.jalz.2013.08.178",

language = "Undefined/Unknown",

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Bazenet, C, Kiddle, S , Sattlecker, M , Proitsi, P , Simmons, A, Westman, E, Nelson, S, Sterling, D, Williams, S , Hodges, A, Johnston, C, Dobson, R, Soininen, H, Kloszewska, I, Mecocci, P, Tsolaki, M, Vellas, B, Newhouse, S , Dobson, RJB & Lovestone, SH 2013, 'Candidate blood proteome markers of Alzheimer's disease onset and progression: A systematic review and replication study', Alzheimer's Dementia: The Journal of the Alzheimer's Association, vol. 9, no. 4, P4-344, pp. P857-P858. https://doi.org/10.1016/j.jalz.2013.08.178

Candidate blood proteome markers of Alzheimer's disease onset and progression: A systematic review and replication study. / Bazenet, Chantal; Kiddle, Steven ; Sattlecker, Martina et al.
In: Alzheimer's Dementia: The Journal of the Alzheimer's Association, Vol. 9, No. 4, P4-344, 2013, p. P857-P858.

Research output: Contribution to journal › Poster abstract › peer-review

TY - JOUR

T1 - Candidate blood proteome markers of Alzheimer's disease onset and progression

T2 - A systematic review and replication study

AU - Bazenet, Chantal

AU - Kiddle, Steven

AU - Sattlecker, Martina

AU - Proitsi, Petroula

AU - Simmons, Andrew

AU - Westman, Eric

AU - Nelson, Sally

AU - Sterling, David

AU - Williams, Steven

AU - Hodges, Angela

AU - Johnston, Caroline

AU - Dobson, Richard

AU - Soininen, Hilkka

AU - Kloszewska, Iwona

AU - Mecocci, Patrizia

AU - Tsolaki, Magda

AU - Vellas, Bruno

AU - Newhouse, Stephen

AU - Dobson, Richard James Butler

AU - Lovestone, Simon H

PY - 2013

Y1 - 2013

N2 - A blood-based protein biomarker, or set of protein biomarkers, that could predict onset and progression of AD would have great utility; potentially clinically, but also for clinical trials and especially in the selection of subjects for preventative trials. Numerous discovery studies for blood-based protein markers of AD have been undertaken during the last decade, ranging from proteomics technologies using both gel and non-gel based mass spectrometry (MS) to antibody capture. The failure to replicate discoveries has been a fundamental issue regarding the development of a useful diagnostic panel to date.

AB - A blood-based protein biomarker, or set of protein biomarkers, that could predict onset and progression of AD would have great utility; potentially clinically, but also for clinical trials and especially in the selection of subjects for preventative trials. Numerous discovery studies for blood-based protein markers of AD have been undertaken during the last decade, ranging from proteomics technologies using both gel and non-gel based mass spectrometry (MS) to antibody capture. The failure to replicate discoveries has been a fundamental issue regarding the development of a useful diagnostic panel to date.

U2 - 10.1016/j.jalz.2013.08.178

DO - 10.1016/j.jalz.2013.08.178

M3 - Poster abstract

VL - 9

SP - P857-P858

JO - Alzheimer's Dementia: The Journal of the Alzheimer's Association

JF - Alzheimer's Dementia: The Journal of the Alzheimer's Association

IS - 4

M1 - P4-344

ER -