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Candidate blood proteome markers of Alzheimer's disease onset and progression: A systematic review and replication study

Research output: Contribution to journalPoster abstract

Chantal Bazenet, Steven Kiddle, Martina Sattlecker, Petroula Proitsi, Andrew Simmons, Eric Westman, Sally Nelson, David Sterling, Steven Williams, Angela Hodges, Caroline Johnston, Richard Dobson, Hilkka Soininen, Iwona Kloszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Stephen Newhouse, Richard James Butler Dobson, Simon H Lovestone

Original languageUndefined/Unknown
Article numberP4-344
Pages (from-to)P857-P858
JournalAlzheimer's Dementia: The Journal of the Alzheimer's Association
Volume9
Issue number4
DOIs
Published2013

King's Authors

Abstract

A blood-based protein biomarker, or set of protein biomarkers, that could predict onset and progression of AD would have great utility; potentially clinically, but also for clinical trials and especially in the selection of subjects for preventative trials. Numerous discovery studies for blood-based protein markers of AD have been undertaken during the last decade, ranging from proteomics technologies using both gel and non-gel based mass spectrometry (MS) to antibody capture. The failure to replicate discoveries has been a fundamental issue regarding the development of a useful diagnostic panel to date.

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