Candidate Gene Analysis of the Human Natural Killer-1 Carbohydrate Pathway and Perineuronal Nets in Schizophrenia: B3GAT2 Is Associated with Disease Risk and Cortical Surface Area

Anna K. Kahler; Srdjan Djurovic; Lars M. Rimol; Andrew Anand Brown; Lavinia Athanasiu; Erik G. Jonsson; Thomas Hansen; Omar Gustafsson; Hakan Hall; Ina Giegling; Pierandrea Muglia; Sven Cichon; Marcella Rietschel; Olli P. H. Pietilainen; Leena Peltonen; Elvira Bramon; David Collier; David St. Clair; Engilbert Sigurdsson; Hannes Petursson; Dan Rujescu; Ingrid Melle; Thomas Werge; Vidar M. Steen; Anders M. Dale; Russell T. Matthews; Ingrid Agartz; Ole A. Andreassen

doi:10.1016/j.biopsych.2010.07.035

Candidate Gene Analysis of the Human Natural Killer-1 Carbohydrate Pathway and Perineuronal Nets in Schizophrenia: B3GAT2 Is Associated with Disease Risk and Cortical Surface Area

Anna K. Kahler
, Srdjan Djurovic
, Lars M. Rimol
, Andrew Anand Brown
, Lavinia Athanasiu
, Erik G. Jonsson
, Thomas Hansen
, Omar Gustafsson
, Hakan Hall
, Ina Giegling
, Pierandrea Muglia
, Sven Cichon
, Marcella Rietschel
, Olli P. H. Pietilainen
, Leena Peltonen
, Elvira Bramon
, David Collier
, David St. Clair
, Engilbert Sigurdsson
, Hannes Petursson

Dan Rujescu, Ingrid Melle, Thomas Werge, Vidar M. Steen, Anders M. Dale, Russell T. Matthews, Ingrid Agartz, Ole A. Andreassen

Univ Oslo, Ullevaal Hosp
University of Oslo
Karolinska University Hospital
Hans Hosp, Res Inst Biol Psychiat
Ludwig Maximilian University of Munich
University of Toronto
University of Bonn
Heidelberg University
Natl Publ Hlth Inst, Dept Mol Med
Wellcome Sanger Institute
Broad Institute of MIT and Harvard
University of Aberdeen
National University Hospital of Iceland
University of Iceland
University of Bergen
Haukeland Hosp
University of California, San Diego
State Univ New York Upstate Med Univ, Dept Neurosci & Physiol
Diakonhjemmet Hosp

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Background: The Human Natural Killer-1 carbohydrate (HNK-1) is involved in neurodevelopment and synaptic plasticity. Extracellular matrix structures called perineuronal nets, condensed around subsets of neurons and proximal dendrites during brain maturation, regulate synaptic transmission and plasticity. Methods: Ten genes of importance for HNK-1 biosynthesis (B3GAT1, B3GAT2, and CHST10) or for the formation of perineuronal nets (TNR, BCAN, NCAN, HAPLN1, HAPLN2, HAPLN3, and HAPLN4) were investigated for potential involvement in schizophrenia (SCZ) susceptibility, by genotyping 104 tagSNPs in the Scandinavian Collaboration on Psychiatric Etiology sample (849 cases; 1602 control subjects). Genome-wide association study imputation data from the European SGENE-plus sample (2663 cases; 13,498 control subjects) were used for comparison. The effect of SCZ risk alleles on brain structure was investigated in a Norwegian subset (98 cases; 177 control subjects) with structural magnetic resonance imaging data. Results: Five single nucleotide polymorphisms (SNPs), located in two adjacent estimated linkage disequilibrium blocks in the first intron of beta-1,3-glucuronyltransferase 2 (B3GAT2), were nominally associated with SCZ (.004

Original language	English
Pages (from-to)	90 - 96
Number of pages	7
Journal	Biological psychiatry
Volume	69
Issue number	1
DOIs	https://doi.org/10.1016/j.biopsych.2010.07.035
Publication status	Published - 1 Jan 2011

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10.1016/j.biopsych.2010.07.035

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Kahler, A. K., Djurovic, S., Rimol, L. M., Brown, A. A., Athanasiu, L., Jonsson, E. G., Hansen, T., Gustafsson, O., Hall, H., Giegling, I., Muglia, P., Cichon, S., Rietschel, M., Pietilainen, O. P. H., Peltonen, L., Bramon, E., Collier, D., Clair, D. S., Sigurdsson, E., ... Andreassen, O. A. (2011). Candidate Gene Analysis of the Human Natural Killer-1 Carbohydrate Pathway and Perineuronal Nets in Schizophrenia: B3GAT2 Is Associated with Disease Risk and Cortical Surface Area. Biological psychiatry, 69(1), 90 - 96. https://doi.org/10.1016/j.biopsych.2010.07.035

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title = "Candidate Gene Analysis of the Human Natural Killer-1 Carbohydrate Pathway and Perineuronal Nets in Schizophrenia: B3GAT2 Is Associated with Disease Risk and Cortical Surface Area",

abstract = "Background: The Human Natural Killer-1 carbohydrate (HNK-1) is involved in neurodevelopment and synaptic plasticity. Extracellular matrix structures called perineuronal nets, condensed around subsets of neurons and proximal dendrites during brain maturation, regulate synaptic transmission and plasticity. Methods: Ten genes of importance for HNK-1 biosynthesis (B3GAT1, B3GAT2, and CHST10) or for the formation of perineuronal nets (TNR, BCAN, NCAN, HAPLN1, HAPLN2, HAPLN3, and HAPLN4) were investigated for potential involvement in schizophrenia (SCZ) susceptibility, by genotyping 104 tagSNPs in the Scandinavian Collaboration on Psychiatric Etiology sample (849 cases; 1602 control subjects). Genome-wide association study imputation data from the European SGENE-plus sample (2663 cases; 13,498 control subjects) were used for comparison. The effect of SCZ risk alleles on brain structure was investigated in a Norwegian subset (98 cases; 177 control subjects) with structural magnetic resonance imaging data. Results: Five single nucleotide polymorphisms (SNPs), located in two adjacent estimated linkage disequilibrium blocks in the first intron of beta-1,3-glucuronyltransferase 2 (B3GAT2), were nominally associated with SCZ (.004 ",

author = "Kahler, \{Anna K.\} and Srdjan Djurovic and Rimol, \{Lars M.\} and Brown, \{Andrew Anand\} and Lavinia Athanasiu and Jonsson, \{Erik G.\} and Thomas Hansen and Omar Gustafsson and Hakan Hall and Ina Giegling and Pierandrea Muglia and Sven Cichon and Marcella Rietschel and Pietilainen, \{Olli P. H.\} and Leena Peltonen and Elvira Bramon and David Collier and Clair, \{David St.\} and Engilbert Sigurdsson and Hannes Petursson and Dan Rujescu and Ingrid Melle and Thomas Werge and Steen, \{Vidar M.\} and Dale, \{Anders M.\} and Matthews, \{Russell T.\} and Ingrid Agartz and Andreassen, \{Ole A.\}",

year = "2011",

month = jan,

day = "1",

doi = "10.1016/j.biopsych.2010.07.035",

language = "English",

volume = "69",

pages = "90 -- 96",

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Kahler, AK, Djurovic, S, Rimol, LM, Brown, AA, Athanasiu, L, Jonsson, EG, Hansen, T, Gustafsson, O, Hall, H, Giegling, I, Muglia, P, Cichon, S, Rietschel, M, Pietilainen, OPH, Peltonen, L, Bramon, E , Collier, D, Clair, DS, Sigurdsson, E, Petursson, H, Rujescu, D, Melle, I, Werge, T, Steen, VM, Dale, AM, Matthews, RT, Agartz, I & Andreassen, OA 2011, 'Candidate Gene Analysis of the Human Natural Killer-1 Carbohydrate Pathway and Perineuronal Nets in Schizophrenia: B3GAT2 Is Associated with Disease Risk and Cortical Surface Area', Biological psychiatry, vol. 69, no. 1, pp. 90 - 96. https://doi.org/10.1016/j.biopsych.2010.07.035

Candidate Gene Analysis of the Human Natural Killer-1 Carbohydrate Pathway and Perineuronal Nets in Schizophrenia: B3GAT2 Is Associated with Disease Risk and Cortical Surface Area. / Kahler, Anna K.; Djurovic, Srdjan; Rimol, Lars M. et al.
In: Biological psychiatry, Vol. 69, No. 1, 01.01.2011, p. 90 - 96.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Candidate Gene Analysis of the Human Natural Killer-1 Carbohydrate Pathway and Perineuronal Nets in Schizophrenia: B3GAT2 Is Associated with Disease Risk and Cortical Surface Area

AU - Kahler, Anna K.

AU - Djurovic, Srdjan

AU - Rimol, Lars M.

AU - Brown, Andrew Anand

AU - Athanasiu, Lavinia

AU - Jonsson, Erik G.

AU - Hansen, Thomas

AU - Gustafsson, Omar

AU - Hall, Hakan

AU - Giegling, Ina

AU - Muglia, Pierandrea

AU - Cichon, Sven

AU - Rietschel, Marcella

AU - Pietilainen, Olli P. H.

AU - Peltonen, Leena

AU - Bramon, Elvira

AU - Collier, David

AU - Clair, David St.

AU - Sigurdsson, Engilbert

AU - Petursson, Hannes

AU - Rujescu, Dan

AU - Melle, Ingrid

AU - Werge, Thomas

AU - Steen, Vidar M.

AU - Dale, Anders M.

AU - Matthews, Russell T.

AU - Agartz, Ingrid

AU - Andreassen, Ole A.

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background: The Human Natural Killer-1 carbohydrate (HNK-1) is involved in neurodevelopment and synaptic plasticity. Extracellular matrix structures called perineuronal nets, condensed around subsets of neurons and proximal dendrites during brain maturation, regulate synaptic transmission and plasticity. Methods: Ten genes of importance for HNK-1 biosynthesis (B3GAT1, B3GAT2, and CHST10) or for the formation of perineuronal nets (TNR, BCAN, NCAN, HAPLN1, HAPLN2, HAPLN3, and HAPLN4) were investigated for potential involvement in schizophrenia (SCZ) susceptibility, by genotyping 104 tagSNPs in the Scandinavian Collaboration on Psychiatric Etiology sample (849 cases; 1602 control subjects). Genome-wide association study imputation data from the European SGENE-plus sample (2663 cases; 13,498 control subjects) were used for comparison. The effect of SCZ risk alleles on brain structure was investigated in a Norwegian subset (98 cases; 177 control subjects) with structural magnetic resonance imaging data. Results: Five single nucleotide polymorphisms (SNPs), located in two adjacent estimated linkage disequilibrium blocks in the first intron of beta-1,3-glucuronyltransferase 2 (B3GAT2), were nominally associated with SCZ (.004

AB - Background: The Human Natural Killer-1 carbohydrate (HNK-1) is involved in neurodevelopment and synaptic plasticity. Extracellular matrix structures called perineuronal nets, condensed around subsets of neurons and proximal dendrites during brain maturation, regulate synaptic transmission and plasticity. Methods: Ten genes of importance for HNK-1 biosynthesis (B3GAT1, B3GAT2, and CHST10) or for the formation of perineuronal nets (TNR, BCAN, NCAN, HAPLN1, HAPLN2, HAPLN3, and HAPLN4) were investigated for potential involvement in schizophrenia (SCZ) susceptibility, by genotyping 104 tagSNPs in the Scandinavian Collaboration on Psychiatric Etiology sample (849 cases; 1602 control subjects). Genome-wide association study imputation data from the European SGENE-plus sample (2663 cases; 13,498 control subjects) were used for comparison. The effect of SCZ risk alleles on brain structure was investigated in a Norwegian subset (98 cases; 177 control subjects) with structural magnetic resonance imaging data. Results: Five single nucleotide polymorphisms (SNPs), located in two adjacent estimated linkage disequilibrium blocks in the first intron of beta-1,3-glucuronyltransferase 2 (B3GAT2), were nominally associated with SCZ (.004

U2 - 10.1016/j.biopsych.2010.07.035

DO - 10.1016/j.biopsych.2010.07.035

M3 - Article

SN - 1873-2402

VL - 69

SP - 90

EP - 96

JO - Biological psychiatry

JF - Biological psychiatry

IS - 1

ER -

Candidate Gene Analysis of the Human Natural Killer-1 Carbohydrate Pathway and Perineuronal Nets in Schizophrenia: B3GAT2 Is Associated with Disease Risk and Cortical Surface Area

Abstract

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