Cannabidiol as a potential treatment for psychosis

C. D. Schubart; I. E C Sommer; P. Fusar-Poli; L. de Witte; R. S. Kahn; M. P M Boks

doi:10.1016/j.euroneuro.2013.11.002

Cannabidiol as a potential treatment for psychosis

C. D. Schubart, I. E C Sommer, P. Fusar-Poli, L. de Witte, R. S. Kahn, M. P M Boks^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

81 Citations (Scopus)

Abstract

Although cannabis use is associated with an increased risk of developing psychosis, the cannabis constituent cannabidiol (CBD) may have antipsychotic properties. This review concisely describes the role of the endocannabinoid system in the development of psychosis and provides an overview of currently available animal, human experimental, imaging, epidemiological and clinical studies that investigated the antipsychotic properties of CBD. In this targeted literature review we performed a search for English articles using Medline and EMBASE. Studies were selected if they described experiments with psychosis models, psychotic symptoms or psychotic disorders as outcome measure and involved the use of CBD as intervention. Evidence from several research domains suggests that CBD shows potential for antipsychotic treatment.

Original language	English
Pages (from-to)	51-64
Number of pages	14
Journal	European Neuropsychopharmacology
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.euroneuro.2013.11.002
Publication status	Published - Jan 2014

Keywords

Antipsychotics
Cannabidiol
Cannabis
Psychosis
Schizophrenia
Treatment

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10.1016/j.euroneuro.2013.11.002

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abstract = "Although cannabis use is associated with an increased risk of developing psychosis, the cannabis constituent cannabidiol (CBD) may have antipsychotic properties. This review concisely describes the role of the endocannabinoid system in the development of psychosis and provides an overview of currently available animal, human experimental, imaging, epidemiological and clinical studies that investigated the antipsychotic properties of CBD. In this targeted literature review we performed a search for English articles using Medline and EMBASE. Studies were selected if they described experiments with psychosis models, psychotic symptoms or psychotic disorders as outcome measure and involved the use of CBD as intervention. Evidence from several research domains suggests that CBD shows potential for antipsychotic treatment.",

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AU - Schubart, C. D.

AU - Sommer, I. E C

AU - Fusar-Poli, P.

AU - de Witte, L.

AU - Kahn, R. S.

AU - Boks, M. P M

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AB - Although cannabis use is associated with an increased risk of developing psychosis, the cannabis constituent cannabidiol (CBD) may have antipsychotic properties. This review concisely describes the role of the endocannabinoid system in the development of psychosis and provides an overview of currently available animal, human experimental, imaging, epidemiological and clinical studies that investigated the antipsychotic properties of CBD. In this targeted literature review we performed a search for English articles using Medline and EMBASE. Studies were selected if they described experiments with psychosis models, psychotic symptoms or psychotic disorders as outcome measure and involved the use of CBD as intervention. Evidence from several research domains suggests that CBD shows potential for antipsychotic treatment.

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Cannabidiol as a potential treatment for psychosis

Abstract

Keywords

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