TY - JOUR
T1 - Cannabis and the Developing Brain
T2 - Insights into Its Long-Lasting Effects
AU - Hurd, Yasmin L.
AU - Manzoni, Olivier J.
AU - Pletnikov, Mikhail V.
AU - Lee, Francis S.
AU - Bhattacharyya, Sagnik
AU - Melis, Miriam
PY - 2019/10/16
Y1 - 2019/10/16
N2 - The recent shift in sociopolitical debates and growing liberalization of cannabis use across the globe has raised concern regarding its impact on vulnerable populations, such as pregnant women and adolescents. Epidemiological studies have long demonstrated a relationship between developmental cannabis exposure and later mental health symptoms. This relationship is especially strong in people with particular genetic polymorphisms, suggesting that cannabis use interacts with genotype to increase mental health risk. Seminal animal research directly linked prenatal and adolescent exposure to delta-9-tetrahydrocannabinol, the major psychoactive component of cannabis, with protracted effects on adult neural systems relevant to psychiatric and substance use disorders. In this article, we discuss some recent advances in understanding the long-term molecular, epigenetic, electrophysiological, and behavioral consequences of prenatal, perinatal, and adolescent exposure to cannabis/delta-9-tetrahydrocannabinol. Insights are provided from both animal and human studies, including in vivo neuroimaging strategies.
AB - The recent shift in sociopolitical debates and growing liberalization of cannabis use across the globe has raised concern regarding its impact on vulnerable populations, such as pregnant women and adolescents. Epidemiological studies have long demonstrated a relationship between developmental cannabis exposure and later mental health symptoms. This relationship is especially strong in people with particular genetic polymorphisms, suggesting that cannabis use interacts with genotype to increase mental health risk. Seminal animal research directly linked prenatal and adolescent exposure to delta-9-tetrahydrocannabinol, the major psychoactive component of cannabis, with protracted effects on adult neural systems relevant to psychiatric and substance use disorders. In this article, we discuss some recent advances in understanding the long-term molecular, epigenetic, electrophysiological, and behavioral consequences of prenatal, perinatal, and adolescent exposure to cannabis/delta-9-tetrahydrocannabinol. Insights are provided from both animal and human studies, including in vivo neuroimaging strategies.
KW - adolescence
KW - cannabis
KW - cognition
KW - perinatal
KW - psychiatric disorders
KW - reward
UR - http://www.scopus.com/inward/record.url?scp=85073430352&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.1165-19.2019
DO - 10.1523/JNEUROSCI.1165-19.2019
M3 - Article
C2 - 31619494
SN - 0270-6474
VL - 39
SP - 8250
EP - 8258
JO - The Journal of neuroscience : the official journal of the Society for Neuroscience
JF - The Journal of neuroscience : the official journal of the Society for Neuroscience
IS - 42
ER -
