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CAR: A key regulator of adhesion and inflammation

Research output: Contribution to journalShort surveypeer-review

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalThe international journal of biochemistry & cell biology
Volume89
Early online date22 May 2017
DOIs
Accepted/In press20 May 2017
E-pub ahead of print22 May 2017
Published1 Aug 2017

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King's Authors

Abstract

The coxsackie and adenovirus receptor (CAR) is a transmembrane receptor that plays a key role in controlling adhesion between adjacent epithelial cells. CAR is highly expressed in epithelial cells and was originally identified as a primary receptor for adenovirus cell binding. However, studies over the last 10 years have demonstrated that CAR plays a key role in co-ordinating cell–cell adhesion under homeostatic conditions including neuronal and cardiac development and cell junction stability; it has also been implicated in pathological states such as cancer growth and leukocyte transmigration during inflammation. Here we provide an overview of the functions of CAR as an adhesion molecule and highlight the emerging important role for CAR in controlling both recruitment of immune cells and in tumorigenesis.

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