CAR: A key regulator of adhesion and inflammation

Elena Ortiz-Zapater; George Santis; Maddy Parsons

doi:10.1016/j.biocel.2017.05.025

CAR: A key regulator of adhesion and inflammation

Elena Ortiz-Zapater, George Santis, Maddy Parsons^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

38 Citations (Scopus)

251 Downloads (Pure)

Abstract

The coxsackie and adenovirus receptor (CAR) is a transmembrane receptor that plays a key role in controlling adhesion between adjacent epithelial cells. CAR is highly expressed in epithelial cells and was originally identified as a primary receptor for adenovirus cell binding. However, studies over the last 10 years have demonstrated that CAR plays a key role in co-ordinating cell–cell adhesion under homeostatic conditions including neuronal and cardiac development and cell junction stability; it has also been implicated in pathological states such as cancer growth and leukocyte transmigration during inflammation. Here we provide an overview of the functions of CAR as an adhesion molecule and highlight the emerging important role for CAR in controlling both recruitment of immune cells and in tumorigenesis.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	The international journal of biochemistry & cell biology
Volume	89
Early online date	22 May 2017
DOIs	https://doi.org/10.1016/j.biocel.2017.05.025
Publication status	Published - 1 Aug 2017

Keywords

Cancer
Cell-cell adhesion
Coxsackievirus adenovirus receptor
Inflammation
Transmigration

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.biocel.2017.05.025Licence: CC BY

CAR A key regulator_ORTIZ-ZAPATER_Publishedonline22May2017_GOLD VoR (CC BY)Final published version, 520 KBLicence: CC BY

Cite this

@article{a98c0c70f5af401cacbb651a8ea8a456,

title = "CAR: A key regulator of adhesion and inflammation",

abstract = "The coxsackie and adenovirus receptor (CAR) is a transmembrane receptor that plays a key role in controlling adhesion between adjacent epithelial cells. CAR is highly expressed in epithelial cells and was originally identified as a primary receptor for adenovirus cell binding. However, studies over the last 10 years have demonstrated that CAR plays a key role in co-ordinating cell–cell adhesion under homeostatic conditions including neuronal and cardiac development and cell junction stability; it has also been implicated in pathological states such as cancer growth and leukocyte transmigration during inflammation. Here we provide an overview of the functions of CAR as an adhesion molecule and highlight the emerging important role for CAR in controlling both recruitment of immune cells and in tumorigenesis.",

keywords = "Cancer, Cell-cell adhesion, Coxsackievirus adenovirus receptor, Inflammation, Transmigration",

author = "Elena Ortiz-Zapater and George Santis and Maddy Parsons",

year = "2017",

month = aug,

day = "1",

doi = "10.1016/j.biocel.2017.05.025",

language = "English",

volume = "89",

pages = "1--5",

journal = "The international journal of biochemistry & cell biology",

issn = "1357-2725",

publisher = "Elsevier",

}

TY - JOUR

T1 - CAR

T2 - A key regulator of adhesion and inflammation

AU - Ortiz-Zapater, Elena

AU - Santis, George

AU - Parsons, Maddy

PY - 2017/8/1

Y1 - 2017/8/1

N2 - The coxsackie and adenovirus receptor (CAR) is a transmembrane receptor that plays a key role in controlling adhesion between adjacent epithelial cells. CAR is highly expressed in epithelial cells and was originally identified as a primary receptor for adenovirus cell binding. However, studies over the last 10 years have demonstrated that CAR plays a key role in co-ordinating cell–cell adhesion under homeostatic conditions including neuronal and cardiac development and cell junction stability; it has also been implicated in pathological states such as cancer growth and leukocyte transmigration during inflammation. Here we provide an overview of the functions of CAR as an adhesion molecule and highlight the emerging important role for CAR in controlling both recruitment of immune cells and in tumorigenesis.

AB - The coxsackie and adenovirus receptor (CAR) is a transmembrane receptor that plays a key role in controlling adhesion between adjacent epithelial cells. CAR is highly expressed in epithelial cells and was originally identified as a primary receptor for adenovirus cell binding. However, studies over the last 10 years have demonstrated that CAR plays a key role in co-ordinating cell–cell adhesion under homeostatic conditions including neuronal and cardiac development and cell junction stability; it has also been implicated in pathological states such as cancer growth and leukocyte transmigration during inflammation. Here we provide an overview of the functions of CAR as an adhesion molecule and highlight the emerging important role for CAR in controlling both recruitment of immune cells and in tumorigenesis.

KW - Cancer

KW - Cell-cell adhesion

KW - Coxsackievirus adenovirus receptor

KW - Inflammation

KW - Transmigration

UR - http://www.scopus.com/inward/record.url?scp=85019607157&partnerID=8YFLogxK

U2 - 10.1016/j.biocel.2017.05.025

DO - 10.1016/j.biocel.2017.05.025

M3 - Short survey

AN - SCOPUS:85019607157

SN - 1357-2725

VL - 89

SP - 1

EP - 5

JO - The international journal of biochemistry & cell biology

JF - The international journal of biochemistry & cell biology

ER -

CAR: A key regulator of adhesion and inflammation

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this