CAR Mechanics: Driving T Cells into the MUC of Cancer

John Maher, Scott Wilkie

Research output: Contribution to journalLiterature reviewpeer-review

32 Citations (Scopus)

Abstract

Several monoclonal antibodies bind in a highly selective manner to tumor-associated glycoforms of MUC1. We set out to exploit this by developing a MUC1-specific chimeric antigen receptor. Difficulties were encountered in this endeavor, owing to MUC1-imposed steric hindrance and antigenic heterogeneity. These issues were addressed by the iterative engineering of all components of the fusion receptor. Our experience underlines the need for careful individual optimization of immunotherapeutic reagents as dictated by the molecular vagaries of the target under study. [Cancer Res 2009;69(11):4559-62]
Original languageEnglish
Pages (from-to)4559 - 4562
Number of pages4
JournalCancer Research
Volume69
Issue number11
DOIs
Publication statusPublished - 1 Jun 2009

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