@article{e31c72065f3747afac33a3b7cf1fa0c8,
title = "Carbon-11 carboxylation of terminal alkynes with [11 C]CO2",
abstract = "A copper-catalysed radiosynthesis of carbon-11 radiolabelled carboxylic acids was developed by reacting terminal alkynes and cyclotron-produced carbon-11 carbon dioxide ([ 11C]CO 2) in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). A small library of 11C-labelled propiolic acid derivatives were obtained with a total synthesis time of 15 min from end of bombardment (EOB) with a (non-isolated) radiochemical yield ranging from 7% to 28%. ",
author = "Francesca Goudou and Gee, {Antony D} and Salvatore Bongarzone",
note = "Funding Information: This project was financially supported by the company PMB. This work was supported by Medical Research Council (MRC, MR/K022733/1 ) and Wellcome/EPSRC Centre for Medical Engineering ( WT 203148/Z/16/Z ). The authors acknowledge the financial support from the Department of Health via the National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre award to Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust and the Centre of Excellence in Medical Engineering funded by the Wellcome Trust and EPSRC under grant number WT 088641/Z/09/Z . Publisher Copyright: {\textcopyright} 2021 The Authors. Journal of Labelled Compounds and Radiopharmaceuticals published by John Wiley & Sons Ltd. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = may,
day = "30",
doi = "10.1002/jlcr.3907",
language = "English",
volume = "64",
pages = "237--242",
journal = "JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS",
issn = "0362-4803",
publisher = "John Wiley & Sons, Ltd",
number = "6",
}