Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [11C]CO2

Salvatore Bongarzone, Nicola Raucci, Igor Camargo Fontana, Federico Luzi, Antony D Gee

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [11C]CO2 and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [11C]CO2 delivery with a trapping efficiency of 21-89%.

Original languageEnglish
Pages (from-to)4668-4671
Number of pages4
JournalChemical communications (Cambridge, England)
Volume56
Issue number34
Early online date25 Mar 2020
DOIs
Publication statusPublished - 30 Apr 2020

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