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Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [11C]CO2

Research output: Contribution to journalArticle

Salvatore Bongarzone, Nicola Raucci, Igor Camargo Fontana, Federico Luzi, Antony D Gee

Original languageEnglish
JournalChemical communications (Cambridge, England)
Publication statusE-pub ahead of print - 25 Mar 2020

King's Authors


A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [11C]CO2 and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [11C]CO2 delivery with a trapping efficiency of 21-89%.

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