Carcinogen-DNA adducts

Annette M Krais; Rajinder  Singh; Volker Manfred Arlt

doi:http://dx.doi.org/10.1016/B978-0-12-801238-3.65219-4

Carcinogen-DNA adducts

Annette M Krais, Rajinder Singh, Volker Manfred Arlt

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Citations (Scopus)

Abstract

Carcinogen-DNA adducts result from the covalent interaction of electrophilic chemical carcinogens with nucleophilic sites in DNA. Some highly reactive genotoxic carcinogens are capable of directly binding to DNA but most carcinogens require metabolic activation. DNA adducts, if not repaired, can lead to mutations, and mutations in critical genes are a characteristic feature of tumors. Thus DNA adduct formation is considered a critical step in the initiation of carcinogenesis. DNA adducts formed in human tissues can be detected by a variety of sensitive techniques including 32P-postlabeling, mass spectrometry, accelerator mass spectrometry, and immunoassays. Their detection and characterization in human tissues can provide clues on the etiology of human cancer.

Original language	English
Title of host publication	Encyclopedia of Cancer
Editors	Paolo Boffetta, Pierre Hainaut
Publisher	Elsevier
Pages	282-295
Volume	1
Edition	3rd
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.65219-4
Publication status	E-pub ahead of print - 5 Nov 2018

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title = "Carcinogen-DNA adducts",

abstract = "Carcinogen-DNA adducts result from the covalent interaction of electrophilic chemical carcinogens with nucleophilic sites in DNA. Some highly reactive genotoxic carcinogens are capable of directly binding to DNA but most carcinogens require metabolic activation. DNA adducts, if not repaired, can lead to mutations, and mutations in critical genes are a characteristic feature of tumors. Thus DNA adduct formation is considered a critical step in the initiation of carcinogenesis. DNA adducts formed in human tissues can be detected by a variety of sensitive techniques including 32P-postlabeling, mass spectrometry, accelerator mass spectrometry, and immunoassays. Their detection and characterization in human tissues can provide clues on the etiology of human cancer.",

author = "Krais, {Annette M} and Rajinder Singh and Arlt, {Volker Manfred}",

year = "2018",

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day = "5",

doi = "http://dx.doi.org/10.1016/B978-0-12-801238-3.65219-4",

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editor = "Boffetta, {Paolo } and Pierre Hainaut",

booktitle = "Encyclopedia of Cancer",

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TY - CHAP

T1 - Carcinogen-DNA adducts

AU - Krais, Annette M

AU - Singh, Rajinder

AU - Arlt, Volker Manfred

PY - 2018/11/5

Y1 - 2018/11/5

N2 - Carcinogen-DNA adducts result from the covalent interaction of electrophilic chemical carcinogens with nucleophilic sites in DNA. Some highly reactive genotoxic carcinogens are capable of directly binding to DNA but most carcinogens require metabolic activation. DNA adducts, if not repaired, can lead to mutations, and mutations in critical genes are a characteristic feature of tumors. Thus DNA adduct formation is considered a critical step in the initiation of carcinogenesis. DNA adducts formed in human tissues can be detected by a variety of sensitive techniques including 32P-postlabeling, mass spectrometry, accelerator mass spectrometry, and immunoassays. Their detection and characterization in human tissues can provide clues on the etiology of human cancer.

AB - Carcinogen-DNA adducts result from the covalent interaction of electrophilic chemical carcinogens with nucleophilic sites in DNA. Some highly reactive genotoxic carcinogens are capable of directly binding to DNA but most carcinogens require metabolic activation. DNA adducts, if not repaired, can lead to mutations, and mutations in critical genes are a characteristic feature of tumors. Thus DNA adduct formation is considered a critical step in the initiation of carcinogenesis. DNA adducts formed in human tissues can be detected by a variety of sensitive techniques including 32P-postlabeling, mass spectrometry, accelerator mass spectrometry, and immunoassays. Their detection and characterization in human tissues can provide clues on the etiology of human cancer.

U2 - http://dx.doi.org/10.1016/B978-0-12-801238-3.65219-4

DO - http://dx.doi.org/10.1016/B978-0-12-801238-3.65219-4

M3 - Chapter

VL - 1

SP - 282

EP - 295

BT - Encyclopedia of Cancer

A2 - Boffetta, Paolo

A2 - Hainaut, Pierre

PB - Elsevier

ER -

Carcinogen-DNA adducts

Abstract

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