Cardiac and respiratory motion correction for simultaneous cardiac PET/MR

Christoph Kolbitsch; Mark A. Ahlman; Cynthia Davies-Venn; Robert Evers; Michael Hansen; Devis Peressutti; Paul Marsden; Peter Kellman; David A. Bluemke; Tobias Schaeffter

doi:10.2967/jnumed.115.171728

Cardiac and respiratory motion correction for simultaneous cardiac PET/MR

Christoph Kolbitsch^*, Mark A. Ahlman, Cynthia Davies-Venn, Robert Evers, Michael Hansen, Devis Peressutti, Paul Marsden, Peter Kellman, David A. Bluemke, Tobias Schaeffter

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

165 Downloads (Pure)

Abstract

Cardiac PET is a versatile imaging technique providing important diagnostic information about ischemic heart diseases. Respiratory and cardiac motion of the heart can strongly impair image quality and therefore diagnostic accuracy of cardiac PET scans. The aim of this study was to investigate a new cardiac PET/MR approach providing respiratory and cardiac motion-compensated MR and PET images in less than 5 min. Methods: Free-breathing 3-dimensional MR data were acquired and retrospectively binned into multiple respiratory and cardiac motion states. Three-dimensional cardiac and respiratory motion fields were obtained with a nonrigid registration algorithm and used in motion-compensated MR and PET reconstructions to improve image quality. The improvement in image quality and diagnostic accuracy of the technique was assessed in simultaneous 18F-FDG PET/MR scans of a canine model of myocardial infarct and was demonstrated in a human subject. Results: MR motion fields were successfully used to compensate for in vivo cardiac motion, leading to improvements in full width at half maximum of the canine myocardium of 13% ± 5%, similar to cardiac gating but with a 90% ± 57% higher contrast-to-noise ratio between myocardium and blood. Motion correction led to an improvement in MR image quality in all subjects, with an increase in sharpness of the canine coronary arteries of 85% ± 72%. A functional assessment showed good agreement with standard MR cine scans with a difference in ejection fraction of 22% ± 3%. MR-based respiratory and cardiac motion information was used to improve the PET image quality of a human in vivo scan. Conclusion: The MR technique presented here provides both diagnostic and motion information that can be used to improve MR and PET image quality. Reliable respiratory and cardiac motion correction could make cardiac PET results more reproducible.

Original language	English
Pages (from-to)	846-852
Number of pages	7
Journal	Journal of Nuclear Medicine
Volume	58
Issue number	5
Early online date	9 Feb 2017
DOIs	https://doi.org/10.2967/jnumed.115.171728
Publication status	Published - 1 May 2017

Keywords

Cardiac and respiratory motion
Cardiac PET
Motion compensation
Radial phase encoding
Simultaneous PET/MR

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2967/jnumed.115.171728

Kolbitsch_jnm_2017Accepted author manuscript, 3.98 MB

Cite this

@article{5989749076e6425baf00920b91c4d659,

title = "Cardiac and respiratory motion correction for simultaneous cardiac PET/MR",

abstract = "Cardiac PET is a versatile imaging technique providing important diagnostic information about ischemic heart diseases. Respiratory and cardiac motion of the heart can strongly impair image quality and therefore diagnostic accuracy of cardiac PET scans. The aim of this study was to investigate a new cardiac PET/MR approach providing respiratory and cardiac motion-compensated MR and PET images in less than 5 min. Methods: Free-breathing 3-dimensional MR data were acquired and retrospectively binned into multiple respiratory and cardiac motion states. Three-dimensional cardiac and respiratory motion fields were obtained with a nonrigid registration algorithm and used in motion-compensated MR and PET reconstructions to improve image quality. The improvement in image quality and diagnostic accuracy of the technique was assessed in simultaneous 18F-FDG PET/MR scans of a canine model of myocardial infarct and was demonstrated in a human subject. Results: MR motion fields were successfully used to compensate for in vivo cardiac motion, leading to improvements in full width at half maximum of the canine myocardium of 13% ± 5%, similar to cardiac gating but with a 90% ± 57% higher contrast-to-noise ratio between myocardium and blood. Motion correction led to an improvement in MR image quality in all subjects, with an increase in sharpness of the canine coronary arteries of 85% ± 72%. A functional assessment showed good agreement with standard MR cine scans with a difference in ejection fraction of 22% ± 3%. MR-based respiratory and cardiac motion information was used to improve the PET image quality of a human in vivo scan. Conclusion: The MR technique presented here provides both diagnostic and motion information that can be used to improve MR and PET image quality. Reliable respiratory and cardiac motion correction could make cardiac PET results more reproducible.",

keywords = "Cardiac and respiratory motion, Cardiac PET, Motion compensation, Radial phase encoding, Simultaneous PET/MR",

author = "Christoph Kolbitsch and Ahlman, {Mark A.} and Cynthia Davies-Venn and Robert Evers and Michael Hansen and Devis Peressutti and Paul Marsden and Peter Kellman and Bluemke, {David A.} and Tobias Schaeffter",

year = "2017",

month = may,

day = "1",

doi = "10.2967/jnumed.115.171728",

language = "English",

volume = "58",

pages = "846--852",

journal = "Journal of Nuclear Medicine",

issn = "0161-5505",

publisher = "Society of Nuclear Medicine Inc.",

number = "5",

}

TY - JOUR

T1 - Cardiac and respiratory motion correction for simultaneous cardiac PET/MR

AU - Kolbitsch, Christoph

AU - Ahlman, Mark A.

AU - Davies-Venn, Cynthia

AU - Evers, Robert

AU - Hansen, Michael

AU - Peressutti, Devis

AU - Marsden, Paul

AU - Kellman, Peter

AU - Bluemke, David A.

AU - Schaeffter, Tobias

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Cardiac PET is a versatile imaging technique providing important diagnostic information about ischemic heart diseases. Respiratory and cardiac motion of the heart can strongly impair image quality and therefore diagnostic accuracy of cardiac PET scans. The aim of this study was to investigate a new cardiac PET/MR approach providing respiratory and cardiac motion-compensated MR and PET images in less than 5 min. Methods: Free-breathing 3-dimensional MR data were acquired and retrospectively binned into multiple respiratory and cardiac motion states. Three-dimensional cardiac and respiratory motion fields were obtained with a nonrigid registration algorithm and used in motion-compensated MR and PET reconstructions to improve image quality. The improvement in image quality and diagnostic accuracy of the technique was assessed in simultaneous 18F-FDG PET/MR scans of a canine model of myocardial infarct and was demonstrated in a human subject. Results: MR motion fields were successfully used to compensate for in vivo cardiac motion, leading to improvements in full width at half maximum of the canine myocardium of 13% ± 5%, similar to cardiac gating but with a 90% ± 57% higher contrast-to-noise ratio between myocardium and blood. Motion correction led to an improvement in MR image quality in all subjects, with an increase in sharpness of the canine coronary arteries of 85% ± 72%. A functional assessment showed good agreement with standard MR cine scans with a difference in ejection fraction of 22% ± 3%. MR-based respiratory and cardiac motion information was used to improve the PET image quality of a human in vivo scan. Conclusion: The MR technique presented here provides both diagnostic and motion information that can be used to improve MR and PET image quality. Reliable respiratory and cardiac motion correction could make cardiac PET results more reproducible.

AB - Cardiac PET is a versatile imaging technique providing important diagnostic information about ischemic heart diseases. Respiratory and cardiac motion of the heart can strongly impair image quality and therefore diagnostic accuracy of cardiac PET scans. The aim of this study was to investigate a new cardiac PET/MR approach providing respiratory and cardiac motion-compensated MR and PET images in less than 5 min. Methods: Free-breathing 3-dimensional MR data were acquired and retrospectively binned into multiple respiratory and cardiac motion states. Three-dimensional cardiac and respiratory motion fields were obtained with a nonrigid registration algorithm and used in motion-compensated MR and PET reconstructions to improve image quality. The improvement in image quality and diagnostic accuracy of the technique was assessed in simultaneous 18F-FDG PET/MR scans of a canine model of myocardial infarct and was demonstrated in a human subject. Results: MR motion fields were successfully used to compensate for in vivo cardiac motion, leading to improvements in full width at half maximum of the canine myocardium of 13% ± 5%, similar to cardiac gating but with a 90% ± 57% higher contrast-to-noise ratio between myocardium and blood. Motion correction led to an improvement in MR image quality in all subjects, with an increase in sharpness of the canine coronary arteries of 85% ± 72%. A functional assessment showed good agreement with standard MR cine scans with a difference in ejection fraction of 22% ± 3%. MR-based respiratory and cardiac motion information was used to improve the PET image quality of a human in vivo scan. Conclusion: The MR technique presented here provides both diagnostic and motion information that can be used to improve MR and PET image quality. Reliable respiratory and cardiac motion correction could make cardiac PET results more reproducible.

KW - Cardiac and respiratory motion

KW - Cardiac PET

KW - Motion compensation

KW - Radial phase encoding

KW - Simultaneous PET/MR

UR - http://www.scopus.com/inward/record.url?scp=85018998040&partnerID=8YFLogxK

U2 - 10.2967/jnumed.115.171728

DO - 10.2967/jnumed.115.171728

M3 - Article

C2 - 28183991

AN - SCOPUS:85018998040

SN - 0161-5505

VL - 58

SP - 846

EP - 852

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

IS - 5

ER -

Cardiac and respiratory motion correction for simultaneous cardiac PET/MR

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this