TY - JOUR
T1 - Cardiac magnetic resonance in patients with ARVC and family members
T2 - the potential role of native T1 mapping
AU - Georgiopoulos, Georgios
AU - Zampieri, Mattia
AU - Molaro, Silvia
AU - Chaloupka, Anna
AU - Aimo, Alberto
AU - Barra, Barbara
AU - Roberts, Leema
AU - Monje-Garcia, Laura
AU - Evans, Colin
AU - Sheikh, Nabeel
AU - Bastiaenen, Rachel
AU - Cooklin, Michael
AU - Masci, Pier Giorgio
AU - Carr-White, Gerald
AU - Finocchiaro, Gherardo
AU - Chiribiri, Amedeo
N1 - Funding Information:
Dr. Georgiopoulos was supported by a Research Fellowship from the European Association of Cardiovascular Imaging and a Postdoctoral Grant from the Alexander S. Onassis Foundation.
Publisher Copyright:
© 2021, The Author(s).
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - Left ventricular (LV) involvement in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) is not evaluated in the revised Task Force Criteria, possibly leading to underdiagnosis. This study explored the diagnostic role of myocardial native T1 mapping in patients with ARVC and their first-degree relatives. Thirty ARVC patients (47% males, mean age 45 ± 27 years) and 59 first-degree relatives not meeting diagnostic criteria underwent CMR with native T1 mapping. C MR was abnormal in 26 (87%) patients with ARVC. The right ventricle was affected in isolation in 13 (43%) patients. Prior to T1 mapping assessment, 2 (7%) patients exhibited isolated LV involvement and 11 (36%) patients showed features of biventricular disease. Left ventricular involvement was manifest as detectable LV late gadolinium enhancement (LGE) in 12 out of 13 cases. According to pre-specified inter-ventricular septal (IVS) T1 mapping thresholds, 11 (37%) patients revealed raised native T1 values including 5 out of the 17 patients who would otherwise have been classified as exhibiting a normal LV by conventional imaging parameters. Native septal T1 values were elevated in 22 (37%) of the 59 first-degree relatives included. Biventricular involvement is commonly observed in ARVC; native myocardial T1 values are raised in more than one third of patients, including a significant proportion of cases that would have been otherwise classified as exhibiting a normal LV using conventional CMR techniques. The significance of abnormal T1 values in first-degree relatives at risk will need validation through longitudinal studies.
AB - Left ventricular (LV) involvement in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) is not evaluated in the revised Task Force Criteria, possibly leading to underdiagnosis. This study explored the diagnostic role of myocardial native T1 mapping in patients with ARVC and their first-degree relatives. Thirty ARVC patients (47% males, mean age 45 ± 27 years) and 59 first-degree relatives not meeting diagnostic criteria underwent CMR with native T1 mapping. C MR was abnormal in 26 (87%) patients with ARVC. The right ventricle was affected in isolation in 13 (43%) patients. Prior to T1 mapping assessment, 2 (7%) patients exhibited isolated LV involvement and 11 (36%) patients showed features of biventricular disease. Left ventricular involvement was manifest as detectable LV late gadolinium enhancement (LGE) in 12 out of 13 cases. According to pre-specified inter-ventricular septal (IVS) T1 mapping thresholds, 11 (37%) patients revealed raised native T1 values including 5 out of the 17 patients who would otherwise have been classified as exhibiting a normal LV by conventional imaging parameters. Native septal T1 values were elevated in 22 (37%) of the 59 first-degree relatives included. Biventricular involvement is commonly observed in ARVC; native myocardial T1 values are raised in more than one third of patients, including a significant proportion of cases that would have been otherwise classified as exhibiting a normal LV using conventional CMR techniques. The significance of abnormal T1 values in first-degree relatives at risk will need validation through longitudinal studies.
KW - ARVC
KW - Diagnosis
KW - Late gadolinium enhancement
KW - T1 mapping
UR - http://www.scopus.com/inward/record.url?scp=85100579513&partnerID=8YFLogxK
U2 - 10.1007/s10554-021-02166-7
DO - 10.1007/s10554-021-02166-7
M3 - Article
C2 - 33550486
AN - SCOPUS:85100579513
SN - 1569-5794
VL - 37
SP - 2037
EP - 2047
JO - INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
JF - INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
IS - 6
ER -