King's College London

Research portal

Cardiac metabolomic profile of the naked mole-rat—glycogen to the rescue

Research output: Contribution to journalArticle

Standard

Cardiac metabolomic profile of the naked mole-rat—glycogen to the rescue. / Faulkes, Chris G.; Eykyn, Thomas R.; Aksentijevic, Dunja.

In: BIOLOGY LETTERS, Vol. 15, No. 11, 20190710, 01.11.2019.

Research output: Contribution to journalArticle

Harvard

Faulkes, CG, Eykyn, TR & Aksentijevic, D 2019, 'Cardiac metabolomic profile of the naked mole-rat—glycogen to the rescue', BIOLOGY LETTERS, vol. 15, no. 11, 20190710. https://doi.org/10.1098/rsbl.2019.0710

APA

Faulkes, C. G., Eykyn, T. R., & Aksentijevic, D. (2019). Cardiac metabolomic profile of the naked mole-rat—glycogen to the rescue. BIOLOGY LETTERS, 15(11), [20190710]. https://doi.org/10.1098/rsbl.2019.0710

Vancouver

Faulkes CG, Eykyn TR, Aksentijevic D. Cardiac metabolomic profile of the naked mole-rat—glycogen to the rescue. BIOLOGY LETTERS. 2019 Nov 1;15(11). 20190710. https://doi.org/10.1098/rsbl.2019.0710

Author

Faulkes, Chris G. ; Eykyn, Thomas R. ; Aksentijevic, Dunja. / Cardiac metabolomic profile of the naked mole-rat—glycogen to the rescue. In: BIOLOGY LETTERS. 2019 ; Vol. 15, No. 11.

Bibtex Download

@article{f1559b7c7bf94b0ba0649686f42c05cb,
title = "Cardiac metabolomic profile of the naked mole-rat—glycogen to the rescue",
abstract = "The African naked mole-rat (Heterocephalus glaber) is unique among mammals, displaying extreme longevity, resistance to cardiovascular disease and an ability to survive long periods of extreme hypoxia. The metabolic adaptations required for resistance to hypoxia are hotly debated and a recent report provides evidence that they are able to switch from glucose to fructose driven glycolysis in the brain. However, other systemic alterations in their metabolism are largely unknown. In the current study, a semi-targeted high resolution 1H magnetic resonance spectroscopy (MRS) metabolomics investigation was performed on cardiac tissue from the naked mole-rat (NMR) and wild-type C57/BL6 mice to better understand these adaptations. A range of metabolic differences was observed in the NMR including increased lactate, consistent with enhanced rates of glycolysis previously reported, increased glutathione, suggesting increased resistance to oxidative stress and decreased succinate/fumarate ratio suggesting reduced oxidative phosphorylation and ROS production. Surprisingly, the most significant difference was an elevation of glycogen stores and glucose-1phosphate resulting from glycogen turnover, that were completely absent in the mouse heart and above the levels found in the mouse liver. Thus, we identified a range of metabolic adaptations in the NMR heart that are relevant to their ability to survive extreme environmental pressures and metabolic stress. Our study underscores the plasticity of energetic pathways and the need for compensatory strategies to adapt in response to the physiological and pathological stress including ageing and ischaemic heart pathologies.",
keywords = "Cardiac metabolism, Glycogen, Hypoxia, Metabolomics, Naked mole-rat",
author = "Faulkes, {Chris G.} and Eykyn, {Thomas R.} and Dunja Aksentijevic",
year = "2019",
month = "11",
day = "1",
doi = "10.1098/rsbl.2019.0710",
language = "English",
volume = "15",
journal = "BIOLOGY LETTERS",
issn = "1744-9561",
publisher = "Royal Society of London",
number = "11",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Cardiac metabolomic profile of the naked mole-rat—glycogen to the rescue

AU - Faulkes, Chris G.

AU - Eykyn, Thomas R.

AU - Aksentijevic, Dunja

PY - 2019/11/1

Y1 - 2019/11/1

N2 - The African naked mole-rat (Heterocephalus glaber) is unique among mammals, displaying extreme longevity, resistance to cardiovascular disease and an ability to survive long periods of extreme hypoxia. The metabolic adaptations required for resistance to hypoxia are hotly debated and a recent report provides evidence that they are able to switch from glucose to fructose driven glycolysis in the brain. However, other systemic alterations in their metabolism are largely unknown. In the current study, a semi-targeted high resolution 1H magnetic resonance spectroscopy (MRS) metabolomics investigation was performed on cardiac tissue from the naked mole-rat (NMR) and wild-type C57/BL6 mice to better understand these adaptations. A range of metabolic differences was observed in the NMR including increased lactate, consistent with enhanced rates of glycolysis previously reported, increased glutathione, suggesting increased resistance to oxidative stress and decreased succinate/fumarate ratio suggesting reduced oxidative phosphorylation and ROS production. Surprisingly, the most significant difference was an elevation of glycogen stores and glucose-1phosphate resulting from glycogen turnover, that were completely absent in the mouse heart and above the levels found in the mouse liver. Thus, we identified a range of metabolic adaptations in the NMR heart that are relevant to their ability to survive extreme environmental pressures and metabolic stress. Our study underscores the plasticity of energetic pathways and the need for compensatory strategies to adapt in response to the physiological and pathological stress including ageing and ischaemic heart pathologies.

AB - The African naked mole-rat (Heterocephalus glaber) is unique among mammals, displaying extreme longevity, resistance to cardiovascular disease and an ability to survive long periods of extreme hypoxia. The metabolic adaptations required for resistance to hypoxia are hotly debated and a recent report provides evidence that they are able to switch from glucose to fructose driven glycolysis in the brain. However, other systemic alterations in their metabolism are largely unknown. In the current study, a semi-targeted high resolution 1H magnetic resonance spectroscopy (MRS) metabolomics investigation was performed on cardiac tissue from the naked mole-rat (NMR) and wild-type C57/BL6 mice to better understand these adaptations. A range of metabolic differences was observed in the NMR including increased lactate, consistent with enhanced rates of glycolysis previously reported, increased glutathione, suggesting increased resistance to oxidative stress and decreased succinate/fumarate ratio suggesting reduced oxidative phosphorylation and ROS production. Surprisingly, the most significant difference was an elevation of glycogen stores and glucose-1phosphate resulting from glycogen turnover, that were completely absent in the mouse heart and above the levels found in the mouse liver. Thus, we identified a range of metabolic adaptations in the NMR heart that are relevant to their ability to survive extreme environmental pressures and metabolic stress. Our study underscores the plasticity of energetic pathways and the need for compensatory strategies to adapt in response to the physiological and pathological stress including ageing and ischaemic heart pathologies.

KW - Cardiac metabolism

KW - Glycogen

KW - Hypoxia

KW - Metabolomics

KW - Naked mole-rat

UR - http://www.scopus.com/inward/record.url?scp=85075690320&partnerID=8YFLogxK

U2 - 10.1098/rsbl.2019.0710

DO - 10.1098/rsbl.2019.0710

M3 - Article

C2 - 31771414

AN - SCOPUS:85075690320

VL - 15

JO - BIOLOGY LETTERS

JF - BIOLOGY LETTERS

SN - 1744-9561

IS - 11

M1 - 20190710

ER -

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454